DegronMD

Uniprot ID: P37198

Source protein: Nuclear pore glycoprotein p62

Source gene: NUP62

Class: DEG_SCF_FBW7_1

Location: 192:198

E3 ligase: FBXW7

DEGRON score: 0.9918

ASA_SCORE: 65.1143

COIL: 0.8777

CONS_SCORE: 0.4735

DSS_SCORE: 0.5937

HELIX: 0.0687

FCONS_SCORE: 1.0717

RIG_SCORE: 0.694

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P192L	TCGA-AA-A01P	COAD	TCGA	PATPAAT	DEG_SCF_FBW7_1	0.6471
p.P192L	DO8642	COAD	ICGC	PATPAAT	DEG_SCF_FBW7_1	0.6471
p.Q204R	TCGA-CC-A5UD	LIHC	TCGA	PATPAAT	DEG_SCF_FBW7_1	0.1667
p.Q204R	DO219552	LIHC	ICGC	PATPAAT	DEG_SCF_FBW7_1	0.1667
p.P185H	TCGA-CV-A45Z	HNSC	TCGA	PATPAAT	DEG_SCF_FBW7_1	0.1389
p.P185H	DO52064	HNSC	ICGC	PATPAAT	DEG_SCF_FBW7_1	0.1389
p.P182T	DO228974	LICA	ICGC	PATPAAT	DEG_SCF_FBW7_1	0.0556
p.T187K	DO229035	LICA	ICGC	PATPAAT	DEG_SCF_FBW7_1	0.1944
p.G201V	DO229053	LICA	ICGC	PATPAAT	DEG_SCF_FBW7_1	0.25
p.T194M	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	PATPAAT	DEG_SCF_FBW7_1	0.7423
p.T194M	ACH-000226	Lymphoma	CCLE	PATPAAT	DEG_SCF_FBW7_1	0.7423
p.T194M	SUP-M2	haematopoietic_and_lymphoid_tissue	COSMIC	PATPAAT	DEG_SCF_FBW7_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P37198	Nuclear pore glycoprotein p62	DEG_SCF_FBW7_1	192:198	PATPAAT	FBXW7	0.9918	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons