DegronMD

Uniprot ID: P0C7A2

Source protein: Protein FAM153B

Source gene: FAM153B

Class: DEG_SCF_FBW7_1

Location: 282:288

E3 ligase: FBXW7

DEGRON score: 0.981

ASA_SCORE: 77.4857

COIL: 0.8846

CONS_SCORE: 1

DSS_SCORE: 0.6951

HELIX: 0.0701

FCONS_SCORE: 1.0476

RIG_SCORE: 0.6823

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P285L	TCGA-A2-A1G0	BRCA	TCGA	PATPAKS	DEG_SCF_FBW7_1	0.7582
p.E278K	TCGA-06-6699	GBM	TCGA	PATPAKS	DEG_SCF_FBW7_1	0.2222
p.P292S	TCGA-GN-A8LK	SKCM	TCGA	PATPAKS	DEG_SCF_FBW7_1	0.2222
p.V276E	TCGA-43-8118	LUSC	TCGA	PATPAKS	DEG_SCF_FBW7_1	0.1667
p.T274N	TCGA-AA-3715	COAD	TCGA	PATPAKS	DEG_SCF_FBW7_1	0.1111

Showing 1 to 5 of 5 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0C7A2	Protein FAM153B	DEG_SCF_FBW7_1	282:288	PATPAKS	FBXW7	0.981	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons