DegronMD - P0C7A2(FAM153B)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E278K	TCGA-06-6699	GBM	TCGA	PATPAKS	DEG_SCF_FBW7_1	282:288	Mutation rewiring degron network	0.2222
p.V276E	TCGA-43-8118	LUSC	TCGA	PATPAKS	DEG_SCF_FBW7_1	282:288	Mutation rewiring degron network	0.1667
p.P285L	TCGA-A2-A1G0	BRCA	TCGA	PATPAKS	DEG_SCF_FBW7_1	282:288	Mutation altering degron motif	0.7582
p.T274N	TCGA-AA-3715	COAD	TCGA	PATPAKS	DEG_SCF_FBW7_1	282:288	Mutation rewiring degron network	0.1111
p.P292S	TCGA-GN-A8LK	SKCM	TCGA	PATPAKS	DEG_SCF_FBW7_1	282:288	Mutation rewiring degron network	0.2222
p.Q252R	CW-2	large intestine	COSMIC	QRGDLEDLE	DEG_APCC_DBOX_1	252:260	Mutation altering degron motif	0.6218

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons