DegronMD

Uniprot ID: P29474

Source protein: Nitric oxide synthase, endothelial

Source gene: NOS3

Class: DEG_SCF_FBW7_2

Location: 31:37

E3 ligase: FBXW7

DEGRON score: 0.9925

ASA_SCORE: 90.4

COIL: 0.964

CONS_SCORE: 0.3115

DSS_SCORE: 0.6464

HELIX: 0.0121

FCONS_SCORE: 1.1087

RIG_SCORE: 0.5732

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R40W	TCGA-B5-A3FC	UCEC	TCGA	PATPAPE	DEG_SCF_FBW7_2	0.25
p.R40W	DO222868	MELA	ICGC	PATPAPE	DEG_SCF_FBW7_2	0.25
p.R40W	DO41871	UCEC	ICGC	PATPAPE	DEG_SCF_FBW7_2	0.25
p.P34S	DO222769	COCA	ICGC	PATPAPE	DEG_SCF_FBW7_2	0.6752
p.L25P	DO228435	MALY	ICGC	PATPAPE	DEG_SCF_FBW7_2	0.1667
p.P47S	DO46503	OV	ICGC	PATPAPE	DEG_SCF_FBW7_2	0.0556
p.T33I	DO218863	SKCA	ICGC	PATPAPE	DEG_SCF_FBW7_2	0.8189
p.A35D	SIDM00521	Small Cell Lung Carcinoma	GDSC	PATPAPE	DEG_SCF_FBW7_2	0.6682
p.S39N	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PATPAPE	DEG_SCF_FBW7_2	0.2778
p.S39N	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PATPAPE	DEG_SCF_FBW7_2	0.2778
p.S39N	ACH-000995	Leukemia	CCLE	PATPAPE	DEG_SCF_FBW7_2	0.2778
p.S39N	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PATPAPE	DEG_SCF_FBW7_2	0.2778
p.A46V	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	PATPAPE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P29474	Nitric oxide synthase, endothelial	DEG_SCF_FBW7_2	31:37	PATPAPE	FBXW7	0.9925	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons