DegronMD - P29474(NOS3)

GO - Biological processes (BP): angiogenesis [GO:0001525]; aortic valve morphogenesis [GO:0003180]; arginine catabolic process [GO:0006527]; blood vessel diameter maintenance [GO:0097746]; blood vessel remodeling [GO:0001974]; cell redox homeostasis [GO:0045454]; endocardial cushion morphogenesis [GO:0003203]; endothelial cell migration [GO:0043542]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; lung development [GO:0030324]; mitochondrion organization [GO:0007005]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of blood pressure [GO:0045776]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of hydrolase activity [GO:0051346]; negative regulation of muscle hyperplasia [GO:0014740]; negative regulation of platelet activation [GO:0010544]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of smooth muscle cell proliferation [GO:0048662]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide mediated signal transduction [GO:0007263]; ovulation from ovarian follicle [GO:0001542]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of gene expression [GO:0010628]; positive regulation of guanylate cyclase activity [GO:0031284]; positive regulation of Notch signaling pathway [GO:0045747]; pulmonary valve morphogenesis [GO:0003184]; regulation of blood pressure [GO:0008217]; regulation of nervous system process [GO:0031644]; regulation of sodium ion transport [GO:0002028]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of the force of heart contraction by chemical signal [GO:0003057]; removal of superoxide radicals [GO:0019430]; response to fluid shear stress [GO:0034405]; response to heat [GO:0009408]; response to hormone [GO:0009725]; response to lipopolysaccharide [GO:0032496]; smooth muscle hyperplasia [GO:0014806]; vasodilation [GO:0042311]; ventricular septum morphogenesis [GO:0060412] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R40W	TCGA-B5-A3FC	UCEC	TCGA	PATPAPE	DEG_SCF_FBW7_2	31:37	Mutation rewiring degron network	0.25
p.R40W	DO222868	MELA	ICGC	PATPAPE	DEG_SCF_FBW7_2	31:37	Mutation rewiring degron network	0.25
p.R40W	DO41871	UCEC	ICGC	PATPAPE	DEG_SCF_FBW7_2	31:37	Mutation rewiring degron network	0.25
p.R97K	TCGA-EY-A1GQ	UCEC	TCGA	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation altering degron motif	0.7237
p.R97K	DO43090	UCEC	ICGC	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation altering degron motif	0.7237
p.A88V	TCGA-FI-A2D5	UCEC	TCGA	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.1111
p.A88V	DO41331	UCEC	ICGC	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.1111
p.K108I	DO230336	COCA	ICGC	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation substituting flanking lysine	0.3333
p.P34S	DO222769	COCA	ICGC	PATPAPE	DEG_SCF_FBW7_2	31:37	Mutation altering degron motif	0.6752
p.A88E	DO228385	LICA	ICGC	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.1111
p.Q110L	DO228617	LICA	ICGC	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.1667
p.A86S	DO229029	LICA	ICGC	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.0556
p.L25P	DO228435	MALY	ICGC	PATPAPE	DEG_SCF_FBW7_2	31:37	Mutation rewiring degron network	0.1667
p.S102F	DO222632	MELA	ICGC	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation altering degron motif	0.7982
p.P47S	DO46503	OV	ICGC	PATPAPE	DEG_SCF_FBW7_2	31:37	Mutation rewiring degron network	0.0556
p.R98C	DO28873	OV	ICGC	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation altering degron motif	0.719
p.T33I	DO218863	SKCA	ICGC	PATPAPE	DEG_SCF_FBW7_2	31:37	Mutation altering degron motif	0.8189
p.A35D	SIDM00521	Small Cell Lung Carcinoma	GDSC	PATPAPE	DEG_SCF_FBW7_2	31:37	Mutation altering degron motif	0.6682
p.R112Q	SIDM01265	Plasma Cell Myeloma	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.1111
p.R112Q	SIDM00338	Acute Myeloid Leukemia	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.1111
p.R112Q	SIDM00855	Other Sarcomas	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.1111
p.R112Q	SIDM00200	Ewing's Sarcoma	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.1111
p.R112Q	SIDM00694	Other Solid Cancers	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.1111
p.R112Q	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.1111
p.R112Q	SIDM00493	Other Solid Cancers	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.1111
p.R112Q	SIDM00863	Burkitt's Lymphoma	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.1111
p.R112Q	SIDM01254	Burkitt's Lymphoma	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.1111
p.S39N	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PATPAPE	DEG_SCF_FBW7_2	31:37	Mutation rewiring degron network	0.2778
p.S39N	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PATPAPE	DEG_SCF_FBW7_2	31:37	Mutation rewiring degron network	0.2778
p.S39N	ACH-000995	Leukemia	CCLE	PATPAPE	DEG_SCF_FBW7_2	31:37	Mutation rewiring degron network	0.2778
p.S39N	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PATPAPE	DEG_SCF_FBW7_2	31:37	Mutation rewiring degron network	0.2778
p.S114F	SIDM01184	Bladder Carcinoma	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation blocking phosphorylation signal	0.5
p.S114F	ACH-000018	Bladder Cancer	CCLE	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation blocking phosphorylation signal	0.5
p.S114F	ACH-000127	Bladder Cancer	CCLE	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation blocking phosphorylation signal	0.5
p.S114F	T-24	urinary tract	COSMIC	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation blocking phosphorylation signal	0.5
p.V104I	SIDM00680	Colorectal Carcinoma	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation altering degron motif	0.5965
p.V104I	ACH-000957	Colon/Colorectal Cancer	CCLE	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation altering degron motif	0.5965
p.V104I	LS-180	large intestine	COSMIC	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation altering degron motif	0.5965
p.A86T	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.0556
p.A86T	ACH-002222	Leukemia	CCLE	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.0556
p.A86T	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.0556
p.G92W	ACH-000747	Lung Cancer	CCLE	PRRCLGSLV	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.2222
p.A46V	DG-75	haematopoietic and lymphoid tissue	COSMIC	PATPAPE	DEG_SCF_FBW7_2	31:37	Mutation rewiring degron network	0.0833

Kaplan plot for NOS3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NOS3

UniProt ID: P29474

Entrez ID: 4846

Protein name: Nitric oxide synthase, endothelial (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (Endothelial NOS) (eNOS) (NOS type III) (NOSIII)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NOS3 in