DegronMD

Uniprot ID: P29474

Source protein: Nitric oxide synthase, endothelial

Source gene: NOS3

Class: DEG_APCC_DBOX_1

Location: 96:104

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9817

ASA_SCORE: 50.9444

COIL: 0.4804

CONS_SCORE: 0.3029

DSS_SCORE: 0.4439

HELIX: 0.078

FCONS_SCORE: 1.2049

RIG_SCORE: 0.7545

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R97K	TCGA-EY-A1GQ	UCEC	TCGA	PRRCLGSLV	DEG_APCC_DBOX_1	0.7237
p.R97K	DO43090	UCEC	ICGC	PRRCLGSLV	DEG_APCC_DBOX_1	0.7237
p.A88V	TCGA-FI-A2D5	UCEC	TCGA	PRRCLGSLV	DEG_APCC_DBOX_1	0.1111
p.A88V	DO41331	UCEC	ICGC	PRRCLGSLV	DEG_APCC_DBOX_1	0.1111
p.K108I	DO230336	COCA	ICGC	PRRCLGSLV	DEG_APCC_DBOX_1	0.3333
p.A88E	DO228385	LICA	ICGC	PRRCLGSLV	DEG_APCC_DBOX_1	0.1111
p.Q110L	DO228617	LICA	ICGC	PRRCLGSLV	DEG_APCC_DBOX_1	0.1667
p.A86S	DO229029	LICA	ICGC	PRRCLGSLV	DEG_APCC_DBOX_1	0.0556
p.S102F	DO222632	MELA	ICGC	PRRCLGSLV	DEG_APCC_DBOX_1	0.7982
p.R98C	DO28873	OV	ICGC	PRRCLGSLV	DEG_APCC_DBOX_1	0.719
p.R112Q	SIDM01265	Plasma Cell Myeloma	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	0.1111
p.R112Q	SIDM00338	Acute Myeloid Leukemia	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	0.1111
p.R112Q	SIDM00855	Other Sarcomas	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	0.1111
p.R112Q	SIDM00200	Ewing's Sarcoma	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	0.1111
p.R112Q	SIDM00694	Other Solid Cancers	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	0.1111
p.R112Q	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	0.1111
p.R112Q	SIDM00493	Other Solid Cancers	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	0.1111
p.R112Q	SIDM00863	Burkitt's Lymphoma	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	0.1111
p.R112Q	SIDM01254	Burkitt's Lymphoma	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	0.1111
p.S114F	SIDM01184	Bladder Carcinoma	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	0.5
p.S114F	ACH-000018	Bladder Cancer	CCLE	PRRCLGSLV	DEG_APCC_DBOX_1	0.5
p.S114F	ACH-000127	Bladder Cancer	CCLE	PRRCLGSLV	DEG_APCC_DBOX_1	0.5
p.S114F	T-24	urinary_tract	COSMIC	PRRCLGSLV	DEG_APCC_DBOX_1	0.5
p.V104I	SIDM00680	Colorectal Carcinoma	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	0.5965
p.V104I	ACH-000957	Colon/Colorectal Cancer	CCLE	PRRCLGSLV	DEG_APCC_DBOX_1	0.5965
p.V104I	LS-180	large_intestine	COSMIC	PRRCLGSLV	DEG_APCC_DBOX_1	0.5965
p.A86T	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PRRCLGSLV	DEG_APCC_DBOX_1	0.0556
p.A86T	ACH-002222	Leukemia	CCLE	PRRCLGSLV	DEG_APCC_DBOX_1	0.0556
p.A86T	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PRRCLGSLV	DEG_APCC_DBOX_1	0.0556
p.G92W	ACH-000747	Lung Cancer	CCLE	PRRCLGSLV	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRRCLGSLV

Degron related mutations and impact score

Drug responses associated with NOS3 mutations

All proteins holding degron of PRRCLGSLV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P29474	Nitric oxide synthase, endothelial	DEG_APCC_DBOX_1	96:104	PRRCLGSLV	APC,CDC20,FZR1	0.9817	More...