DegronMD

Uniprot ID: Q9H156

Source protein: SLIT and NTRK-like protein 2

Source gene: SLITRK2

Class: DEG_SCF_FBW7_1

Location: 730:736

E3 ligase: FBXW7

DEGRON score: 0.997

ASA_SCORE: 69.0571

COIL: 0.833

CONS_SCORE: 0.5043

DSS_SCORE: 0.4957

HELIX: 0.0577

FCONS_SCORE: 0.8846

RIG_SCORE: 0.7242

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P733T	TCGA-50-7109	LUAD	TCGA	PATPAYT	DEG_SCF_FBW7_1	0.7031
p.P733T	DO24487	LUAD	ICGC	PATPAYT	DEG_SCF_FBW7_1	0.7031
p.E744Q	TCGA-AC-A23H	BRCA	TCGA	PATPAYT	DEG_SCF_FBW7_1	0.1111
p.E744Q	DO2401	BRCA	ICGC	PATPAYT	DEG_SCF_FBW7_1	0.1111
p.A739V	TCGA-BR-8361	STAD	TCGA	PATPAYT	DEG_SCF_FBW7_1	0.25
p.A739V	DO48032	STAD	ICGC	PATPAYT	DEG_SCF_FBW7_1	0.25
p.T740A	TCGA-FI-A2D0	UCEC	TCGA	PATPAYT	DEG_SCF_FBW7_1	0.2222
p.T740A	DO43891	UCEC	ICGC	PATPAYT	DEG_SCF_FBW7_1	0.2222
p.N722K	TCGA-KU-A66S	HNSC	TCGA	PATPAYT	DEG_SCF_FBW7_1	0.1111
p.N722K	DO44456	HNSC	ICGC	PATPAYT	DEG_SCF_FBW7_1	0.1111
p.N722S	DO222494	MELA	ICGC	PATPAYT	DEG_SCF_FBW7_1	0.1111
p.P733L	SIDM00845	Burkitt's Lymphoma	GDSC	PATPAYT	DEG_SCF_FBW7_1	0.7582
p.P733L	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PATPAYT	DEG_SCF_FBW7_1	0.7582
p.E725K	SIDM00190	Melanoma	GDSC	PATPAYT	DEG_SCF_FBW7_1	0.1944
p.E725K	ACH-002097	Skin Cancer	CCLE	PATPAYT	DEG_SCF_FBW7_1	0.1944
p.E725K	CP66-MEL	skin	COSMIC	PATPAYT	DEG_SCF_FBW7_1	0.1944
p.E725D	SIDM00889	Cervical Carcinoma	GDSC	PATPAYT	DEG_SCF_FBW7_1	0.1944
p.E725D	ACH-001333	Cervical Cancer	CCLE	PATPAYT	DEG_SCF_FBW7_1	0.1944
p.E725D	C-33-A	cervix	COSMIC	PATPAYT	DEG_SCF_FBW7_1	0.1944
p.T732K	SIDM00665	Gastric Carcinoma	GDSC	PATPAYT	DEG_SCF_FBW7_1	0.8417
p.T732K	ACH-000616	Gastric Cancer	CCLE	PATPAYT	DEG_SCF_FBW7_1	0.8417
p.T732K	Hs746T	stomach	COSMIC	PATPAYT	DEG_SCF_FBW7_1	0.8417
p.A731G	SIDM00044	Head and Neck Carcinoma	GDSC	PATPAYT	DEG_SCF_FBW7_1	0.6429
p.A731G	ACH-002295	Head and Neck Cancer	CCLE	PATPAYT	DEG_SCF_FBW7_1	0.6429
p.A731G	PCI-30	upper_aerodigestive_tract	COSMIC	PATPAYT	DEG_SCF_FBW7_1	0.6429
p.Y720H	SIDM01608	Endometrial Carcinoma	GDSC	PATPAYT	DEG_SCF_FBW7_1	0.0556
p.Y720H	ACH-000990	Endometrial/Uterine Cancer	CCLE	PATPAYT	DEG_SCF_FBW7_1	0.0556
p.A731V	SIDM01617	Endometrial Carcinoma	GDSC	PATPAYT	DEG_SCF_FBW7_1	0.5825
p.A731V	ACH-000994	Endometrial/Uterine Cancer	CCLE	PATPAYT	DEG_SCF_FBW7_1	0.5825
p.E728K	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	PATPAYT	DEG_SCF_FBW7_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATPAYT

Degron related mutations and impact score

Drug responses associated with SLITRK2 mutations

All proteins holding degron of PATPAYT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H156	SLIT and NTRK-like protein 2	DEG_SCF_FBW7_1	730:736	PATPAYT	FBXW7	0.997	More...