DegronMD - Q9H156(SLITRK2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K306T	TCGA-2E-A9G8	UCEC	TCGA	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation substituting flanking lysine	0.3056
p.K306T	DO219763	UCEC	ICGC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation substituting flanking lysine	0.3056
p.P304T	TCGA-44-7661	LUAD	TCGA	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.1389
p.P304T	DO23602	LUAD	ICGC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.1389
p.P304T	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.1389
p.P304T	ACH-000733	Lung Cancer	CCLE	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.1389
p.P304T	NCI-H1838	lung	COSMIC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.1389
p.P311T	TCGA-44-7671	LUAD	TCGA	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation altering degron motif	0.7031
p.P311T	DO25252	LUAD	ICGC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation altering degron motif	0.7031
p.P311A	TCGA-50-5941	LUAD	TCGA	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation altering degron motif	0.7503
p.P311A	DO25528	LUAD	ICGC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation altering degron motif	0.7503
p.P733T	TCGA-50-7109	LUAD	TCGA	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation altering degron motif	0.7031
p.P733T	DO24487	LUAD	ICGC	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation altering degron motif	0.7031
p.S302N	TCGA-AA-3672	COAD	TCGA	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation blocking phosphorylation signal	0.5278
p.S302N	DO9010	COAD	ICGC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation blocking phosphorylation signal	0.5278
p.E744Q	TCGA-AC-A23H	BRCA	TCGA	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation rewiring degron network	0.1111
p.E744Q	DO2401	BRCA	ICGC	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation rewiring degron network	0.1111
p.R310C	TCGA-AP-A051	UCEC	TCGA	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.3056
p.R310C	DO222650	BTCA	ICGC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.3056
p.R310C	DO222762	COCA	ICGC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.3056
p.R310C	DO222868	MELA	ICGC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.3056
p.R310C	DO42673	UCEC	ICGC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.3056
p.R310C	SIDM00534	Colorectal Carcinoma	GDSC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.3056
p.R310C	ACH-000986	Colon/Colorectal Cancer	CCLE	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.3056
p.R310C	HT-115	large intestine	COSMIC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.3056
p.P326S	TCGA-AX-A1C9	UCEC	TCGA	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.0556
p.P326S	TCGA-ZH-A8Y2	CHOL	TCGA	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.0556
p.P326S	DO43098	UCEC	ICGC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.0556
p.K319N	TCGA-AX-A2HC	UCEC	TCGA	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation substituting flanking lysine	0.3611
p.K319N	DO41572	UCEC	ICGC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation substituting flanking lysine	0.3611
p.R314Q	TCGA-B5-A0JY	UCEC	TCGA	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation altering degron motif	0.6218
p.R314Q	TCGA-EO-A22R	UCEC	TCGA	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation altering degron motif	0.6218
p.R314Q	DO43041	UCEC	ICGC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation altering degron motif	0.6218
p.R314Q	DO42713	UCEC	ICGC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation altering degron motif	0.6218
p.R303Q	TCGA-B6-A0I9	BRCA	TCGA	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.1111
p.R303Q	TCGA-BR-4368	STAD	TCGA	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.1111
p.R303Q	DO5863	BRCA	ICGC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.1111
p.R303Q	DO36969	READ	ICGC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.1111
p.R303Q	DO38715	STAD	ICGC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.1111
p.A739V	TCGA-BR-8361	STAD	TCGA	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation rewiring degron network	0.25
p.A739V	DO48032	STAD	ICGC	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation rewiring degron network	0.25
p.R310H	TCGA-D6-A6EN	HNSC	TCGA	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.3056
p.R310H	DO233747	GACA	ICGC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.3056
p.R310H	DO223266	HNSC	ICGC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.3056
p.T740A	TCGA-FI-A2D0	UCEC	TCGA	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation rewiring degron network	0.2222
p.T740A	DO43891	UCEC	ICGC	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation rewiring degron network	0.2222
p.N722K	TCGA-KU-A66S	HNSC	TCGA	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation rewiring degron network	0.1111
p.N722K	DO44456	HNSC	ICGC	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation rewiring degron network	0.1111
p.P304L	TCGA-VS-A9UI	CESC	TCGA	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.1389
p.P304L	DO219734	CESC	ICGC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.1389
p.V315M	DO223066	ESCA	ICGC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation altering degron motif	0.6097
p.R308K	DO233281	GACA	ICGC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.25
p.P304S	DO23324	LINC	ICGC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.1389
p.N722S	DO222494	MELA	ICGC	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation rewiring degron network	0.1111
p.D320E	DO232832	NACA	ICGC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.2222
p.P733L	SIDM00845	Burkitt's Lymphoma	GDSC	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation altering degron motif	0.7582
p.P733L	Daudi	haematopoietic and lymphoid tissue	COSMIC	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation altering degron motif	0.7582
p.E725K	SIDM00190	Melanoma	GDSC	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation rewiring degron network	0.1944
p.E725K	ACH-002097	Skin Cancer	CCLE	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation rewiring degron network	0.1944
p.E725K	CP66-MEL	skin	COSMIC	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation rewiring degron network	0.1944
p.E725D	SIDM00889	Cervical Carcinoma	GDSC	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation rewiring degron network	0.1944
p.E725D	ACH-001333	Cervical Cancer	CCLE	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation rewiring degron network	0.1944
p.E725D	C-33-A	cervix	COSMIC	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation rewiring degron network	0.1944
p.T732K	SIDM00665	Gastric Carcinoma	GDSC	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation altering degron motif	0.8417
p.T732K	ACH-000616	Gastric Cancer	CCLE	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation altering degron motif	0.8417
p.T732K	Hs746T	stomach	COSMIC	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation altering degron motif	0.8417
p.A731G	SIDM00044	Head and Neck Carcinoma	GDSC	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation altering degron motif	0.6429
p.A731G	ACH-002295	Head and Neck Cancer	CCLE	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation altering degron motif	0.6429
p.A731G	PCI-30	upper aerodigestive tract	COSMIC	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation altering degron motif	0.6429
p.Y720H	SIDM01608	Endometrial Carcinoma	GDSC	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation rewiring degron network	0.0556
p.Y720H	ACH-000990	Endometrial/Uterine Cancer	CCLE	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation rewiring degron network	0.0556
p.A731V	SIDM01617	Endometrial Carcinoma	GDSC	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation altering degron motif	0.5825
p.A731V	ACH-000994	Endometrial/Uterine Cancer	CCLE	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation altering degron motif	0.5825
p.S318L	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.2778
p.S318L	ACH-000912	Lung Cancer	CCLE	PTPRVT	DEG_SCF_FBW7_1	311:316	Mutation rewiring degron network	0.2778
p.E728K	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	PATPAYT	DEG_SCF_FBW7_1	730:736	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLITRK2

UniProt ID: Q9H156

Entrez ID: 84631

Protein name: SLIT and NTRK-like protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLITRK2 in