DegronMD

Uniprot ID: Q9H156

Source protein: SLIT and NTRK-like protein 2

Source gene: SLITRK2

Class: DEG_SCF_FBW7_1

Location: 311:316

E3 ligase: FBXW7

DEGRON score: 0.9936

ASA_SCORE: 66.3167

COIL: 0.8207

CONS_SCORE: 0.753

DSS_SCORE: 0.7673

HELIX: 0.0467

FCONS_SCORE: 1.1013

RIG_SCORE: 0.6684

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K306T	TCGA-2E-A9G8	UCEC	TCGA	PTPRVT	DEG_SCF_FBW7_1	0.3056
p.K306T	DO219763	UCEC	ICGC	PTPRVT	DEG_SCF_FBW7_1	0.3056
p.P304T	TCGA-44-7661	LUAD	TCGA	PTPRVT	DEG_SCF_FBW7_1	0.1389
p.P304T	DO23602	LUAD	ICGC	PTPRVT	DEG_SCF_FBW7_1	0.1389
p.P304T	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	PTPRVT	DEG_SCF_FBW7_1	0.1389
p.P304T	ACH-000733	Lung Cancer	CCLE	PTPRVT	DEG_SCF_FBW7_1	0.1389
p.P304T	NCI-H1838	lung	COSMIC	PTPRVT	DEG_SCF_FBW7_1	0.1389
p.P311T	TCGA-44-7671	LUAD	TCGA	PTPRVT	DEG_SCF_FBW7_1	0.7031
p.P311T	DO25252	LUAD	ICGC	PTPRVT	DEG_SCF_FBW7_1	0.7031
p.P311A	TCGA-50-5941	LUAD	TCGA	PTPRVT	DEG_SCF_FBW7_1	0.7503
p.P311A	DO25528	LUAD	ICGC	PTPRVT	DEG_SCF_FBW7_1	0.7503
p.S302N	TCGA-AA-3672	COAD	TCGA	PTPRVT	DEG_SCF_FBW7_1	0.5278
p.S302N	DO9010	COAD	ICGC	PTPRVT	DEG_SCF_FBW7_1	0.5278
p.R310C	TCGA-AP-A051	UCEC	TCGA	PTPRVT	DEG_SCF_FBW7_1	0.3056
p.R310C	DO222650	BTCA	ICGC	PTPRVT	DEG_SCF_FBW7_1	0.3056
p.R310C	DO222762	COCA	ICGC	PTPRVT	DEG_SCF_FBW7_1	0.3056
p.R310C	DO222868	MELA	ICGC	PTPRVT	DEG_SCF_FBW7_1	0.3056
p.R310C	DO42673	UCEC	ICGC	PTPRVT	DEG_SCF_FBW7_1	0.3056
p.R310C	SIDM00534	Colorectal Carcinoma	GDSC	PTPRVT	DEG_SCF_FBW7_1	0.3056
p.R310C	ACH-000986	Colon/Colorectal Cancer	CCLE	PTPRVT	DEG_SCF_FBW7_1	0.3056
p.R310C	HT-115	large_intestine	COSMIC	PTPRVT	DEG_SCF_FBW7_1	0.3056
p.P326S	TCGA-AX-A1C9	UCEC	TCGA	PTPRVT	DEG_SCF_FBW7_1	0.0556
p.P326S	TCGA-ZH-A8Y2	CHOL	TCGA	PTPRVT	DEG_SCF_FBW7_1	0.0556
p.P326S	DO43098	UCEC	ICGC	PTPRVT	DEG_SCF_FBW7_1	0.0556
p.K319N	TCGA-AX-A2HC	UCEC	TCGA	PTPRVT	DEG_SCF_FBW7_1	0.3611
p.K319N	DO41572	UCEC	ICGC	PTPRVT	DEG_SCF_FBW7_1	0.3611
p.R314Q	TCGA-B5-A0JY	UCEC	TCGA	PTPRVT	DEG_SCF_FBW7_1	0.6218
p.R314Q	TCGA-EO-A22R	UCEC	TCGA	PTPRVT	DEG_SCF_FBW7_1	0.6218
p.R314Q	DO43041	UCEC	ICGC	PTPRVT	DEG_SCF_FBW7_1	0.6218
p.R314Q	DO42713	UCEC	ICGC	PTPRVT	DEG_SCF_FBW7_1	0.6218
p.R303Q	TCGA-B6-A0I9	BRCA	TCGA	PTPRVT	DEG_SCF_FBW7_1	0.1111
p.R303Q	TCGA-BR-4368	STAD	TCGA	PTPRVT	DEG_SCF_FBW7_1	0.1111
p.R303Q	DO5863	BRCA	ICGC	PTPRVT	DEG_SCF_FBW7_1	0.1111
p.R303Q	DO36969	READ	ICGC	PTPRVT	DEG_SCF_FBW7_1	0.1111
p.R303Q	DO38715	STAD	ICGC	PTPRVT	DEG_SCF_FBW7_1	0.1111
p.R310H	TCGA-D6-A6EN	HNSC	TCGA	PTPRVT	DEG_SCF_FBW7_1	0.3056
p.R310H	DO233747	GACA	ICGC	PTPRVT	DEG_SCF_FBW7_1	0.3056
p.R310H	DO223266	HNSC	ICGC	PTPRVT	DEG_SCF_FBW7_1	0.3056
p.P304L	TCGA-VS-A9UI	CESC	TCGA	PTPRVT	DEG_SCF_FBW7_1	0.1389
p.P304L	DO219734	CESC	ICGC	PTPRVT	DEG_SCF_FBW7_1	0.1389
p.V315M	DO223066	ESCA	ICGC	PTPRVT	DEG_SCF_FBW7_1	0.6097
p.R308K	DO233281	GACA	ICGC	PTPRVT	DEG_SCF_FBW7_1	0.25
p.P304S	DO23324	LINC	ICGC	PTPRVT	DEG_SCF_FBW7_1	0.1389
p.D320E	DO232832	NACA	ICGC	PTPRVT	DEG_SCF_FBW7_1	0.2222
p.S318L	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	PTPRVT	DEG_SCF_FBW7_1	0.2778
p.S318L	ACH-000912	Lung Cancer	CCLE	PTPRVT	DEG_SCF_FBW7_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPRVT

Degron related mutations and impact score

Drug responses associated with SLITRK2 mutations

All proteins holding degron of PTPRVT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H156	SLIT and NTRK-like protein 2	DEG_SCF_FBW7_1	311:316	PTPRVT	FBXW7	0.9936	More...