DegronMD

Uniprot ID: Q93008

Source protein: Probable ubiquitin carboxyl-terminal hydrolase FAF-X

Source gene: USP9X

Class: DEG_SCF_FBW7_2

Location: 44:50

E3 ligase: FBXW7

DEGRON score: 0.9886

ASA_SCORE: 96.7429

COIL: 0.9211

CONS_SCORE: 0.314

DSS_SCORE: 0.9805

HELIX: 0.0659

FCONS_SCORE: 1.1037

RIG_SCORE: 0.4797

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P58Q	TCGA-18-3410	LUSC	TCGA	PATPPDE	DEG_SCF_FBW7_2	0.1111
p.P58Q	DO26456	LUSC	ICGC	PATPPDE	DEG_SCF_FBW7_2	0.1111
p.A56V	TCGA-DQ-5625	HNSC	TCGA	PATPPDE	DEG_SCF_FBW7_2	0.1667
p.A56V	DO15414	HNSC	ICGC	PATPPDE	DEG_SCF_FBW7_2	0.1667
p.P44T	TCGA-EE-A3AA	SKCM	TCGA	PATPPDE	DEG_SCF_FBW7_2	0.7031
p.P44T	DO37571	SKCM	ICGC	PATPPDE	DEG_SCF_FBW7_2	0.7031
p.E50D	DO229029	LICA	ICGC	PATPPDE	DEG_SCF_FBW7_2	0.6758
p.P44L	DO33208	PACA	ICGC	PATPPDE	DEG_SCF_FBW7_2	0.6471
p.Q51E	SIDM01624	Bladder Carcinoma	GDSC	PATPPDE	DEG_SCF_FBW7_2	0.3056
p.Q51E	ACH-000026	Bladder Cancer	CCLE	PATPPDE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q93008	Probable ubiquitin carboxyl-terminal hydrolase FAF-X	DEG_SCF_FBW7_2	44:50	PATPPDE	FBXW7	0.9886	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons