DegronMD

Uniprot ID: Q9NZU7

Source protein: Calcium-binding protein 1

Source gene: CABP1

Class: DEG_SCF_FBW7_1

Location: 106:112

E3 ligase: FBXW7

DEGRON score: 0.9869

ASA_SCORE: 87.9571

COIL: 0.9573

CONS_SCORE: 0.4582

DSS_SCORE: 0.7959

HELIX: 0.0219

FCONS_SCORE: 1.0013

RIG_SCORE: 0.5022

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E118K	DO51612	CESC	ICGC	PATPQSS	DEG_SCF_FBW7_1	0.1667
p.A114V	DO230342	COCA	ICGC	PATPQSS	DEG_SCF_FBW7_1	0.2778
p.E98Q	DO14566	HNSC	ICGC	PATPQSS	DEG_SCF_FBW7_1	0.5556
p.T108K	DO27357	LUSC	ICGC	PATPQSS	DEG_SCF_FBW7_1	0.7306
p.R118Q	DO222405	MELA	ICGC	PATPQSS	DEG_SCF_FBW7_1	0.1667
p.G121R	DO222423	MELA	ICGC	PATPQSS	DEG_SCF_FBW7_1	0.0833
p.G121R	DO37425	SKCM	ICGC	PATPQSS	DEG_SCF_FBW7_1	0.0833
p.M121I	ACH-000707	Lymphoma	CCLE	PATPQSS	DEG_SCF_FBW7_1	0.0833
p.P118S	ACH-000925	Lung Cancer	CCLE	PATPQSS	DEG_SCF_FBW7_1	0.1667
p.R112C	ACH-000953	Leukemia	CCLE	PATPQSS	DEG_SCF_FBW7_1	0.8301
p.R112C	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PATPQSS	DEG_SCF_FBW7_1	0.8301
p.E110K	Hs939-T	skin	COSMIC	PATPQSS	DEG_SCF_FBW7_1	0.7022
p.M121L	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PATPQSS	DEG_SCF_FBW7_1	0.0833
p.P122L	H2591	pleura	COSMIC	PATPQSS	DEG_SCF_FBW7_1	0.0556
p.A117V	MFE-319	endometrium	COSMIC	PATPQSS	DEG_SCF_FBW7_1	0.1944
p.V106M	SW684	soft_tissue	COSMIC	PATPQSS	DEG_SCF_FBW7_1	0.7208

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZU7	Calcium-binding protein 1	DEG_SCF_FBW7_1	106:112	PATPQSS	FBXW7	0.9869	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons