DegronMD

Uniprot ID: Q32P44

Source protein: Echinoderm microtubule-associated protein-like 3

Source gene: EML3

Class: DEG_SCF_FBW7_1

Location: 879:885

E3 ligase: FBXW7

DEGRON score: 0.619

ASA_SCORE: 77.9571

COIL: 0.7596

CONS_SCORE: 0.3022

DSS_SCORE: 0.6209

HELIX: 0.026

FCONS_SCORE: 0.9449

RIG_SCORE: 0.6227

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S874L	DO44373	CESC	ICGC	PATPSRT	DEG_SCF_FBW7_1	0.1944
p.H887N	DO228974	LICA	ICGC	PATPSRT	DEG_SCF_FBW7_1	0.7222
p.H887N	DO229025	LICA	ICGC	PATPSRT	DEG_SCF_FBW7_1	0.7222
p.N882K	DO47542	SKCM	ICGC	PATPSRT	DEG_SCF_FBW7_1	0.6918
p.P876L	SIDM00520	Mesothelioma	GDSC	PATPSRT	DEG_SCF_FBW7_1	0.25
p.P876L	SIDM01037	Breast Carcinoma	GDSC	PATPSRT	DEG_SCF_FBW7_1	0.25
p.G894V	SIDM01100	Neuroblastoma	GDSC	PATPSRT	DEG_SCF_FBW7_1	0.0833
p.G894V	SK-N-DZ	autonomic_ganglia	COSMIC	PATPSRT	DEG_SCF_FBW7_1	0.0833
p.P886L	ACH-000968	Skin Cancer	CCLE	PATPSRT	DEG_SCF_FBW7_1	0.3056
p.P886L	COLO-792	skin	COSMIC	PATPSRT	DEG_SCF_FBW7_1	0.3056
p.P886S	ACH-000968	Skin Cancer	CCLE	PATPSRT	DEG_SCF_FBW7_1	0.3056
p.P886S	COLO-792	skin	COSMIC	PATPSRT	DEG_SCF_FBW7_1	0.3056
p.C878R	22RV1	prostate	COSMIC	PATPSRT	DEG_SCF_FBW7_1	0.3056
p.A884T	UWB1_289	ovary	COSMIC	PATPSRT	DEG_SCF_FBW7_1	0.7139
p.P887S	COLO-792	skin	COSMIC	PATPSRT	DEG_SCF_FBW7_1	0.7222
p.P887L	COLO-792	skin	COSMIC	PATPSRT	DEG_SCF_FBW7_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q32P44	Echinoderm microtubule-associated protein-like 3	DEG_SCF_FBW7_1	879:885	PATPSRT	FBXW7	0.619	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons