DegronMD

Uniprot ID: Q12888

Source protein: TP53-binding protein 1

Source gene: TP53BP1

Class: DEG_SCF_FBW7_1

Location: 1636:1642

E3 ligase: FBXW7

DEGRON score: 0.9715

ASA_SCORE: 94.9429

COIL: 0.9566

CONS_SCORE: 0.3219

DSS_SCORE: 0.6949

HELIX: 0.0234

FCONS_SCORE: 0.6927

RIG_SCORE: 0.557

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1641S	TCGA-4Z-AA7O	BLCA	TCGA	PATPTAS	DEG_SCF_FBW7_1	0.6752
p.A1646T	TCGA-AP-A059	UCEC	TCGA	PATPTAS	DEG_SCF_FBW7_1	0.6667
p.R1632L	TCGA-D3-A2JC	SKCM	TCGA	PATPTAS	DEG_SCF_FBW7_1	0.2222
p.P1636S	DO51865	BLCA	ICGC	PATPTAS	DEG_SCF_FBW7_1	0.6752
p.R1627L	DO47578	SKCM	ICGC	PATPTAS	DEG_SCF_FBW7_1	0.0833
p.A1641T	DO41361	UCEC	ICGC	PATPTAS	DEG_SCF_FBW7_1	0.6028
p.T1652I	SIDM01283	Esophageal Carcinoma	GDSC	PATPTAS	DEG_SCF_FBW7_1	0.1667
p.S1647A	SIDM00845	Burkitt's Lymphoma	GDSC	PATPTAS	DEG_SCF_FBW7_1	0.6389
p.S1640F	SIDM00107	Melanoma	GDSC	PATPTAS	DEG_SCF_FBW7_1	0.7982
p.S1640F	UACC-62	skin	COSMIC	PATPTAS	DEG_SCF_FBW7_1	0.7982
p.V1638I	SIDM00375	Head and Neck Carcinoma	GDSC	PATPTAS	DEG_SCF_FBW7_1	0.7076
p.V1638I	SKN-3	upper_aerodigestive_tract	COSMIC	PATPTAS	DEG_SCF_FBW7_1	0.7076
p.V1649A	ACH-000948	Gastric Cancer	CCLE	PATPTAS	DEG_SCF_FBW7_1	0.1389
p.V1649A	23132-87	stomach	COSMIC	PATPTAS	DEG_SCF_FBW7_1	0.1389
p.S1635F	UACC-62	skin	COSMIC	PATPTAS	DEG_SCF_FBW7_1	0.75
p.V1633I	SKN-3	upper_aerodigestive_tract	COSMIC	PATPTAS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12888	TP53-binding protein 1	DEG_SCF_FBW7_1	1636:1642	PATPTAS	FBXW7	0.9715	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons