DegronMD

Uniprot ID: Q674R7

Source protein: Autophagy-related protein 9B

Source gene: ATG9B

Class: DEG_SCF_FBW7_1

Location: 124:130

E3 ligase: FBXW7

DEGRON score: 0.9689

ASA_SCORE: 77.4714

COIL: 0.9217

CONS_SCORE: 0.2234

DSS_SCORE: 0.8012

HELIX: 0.0583

FCONS_SCORE: 0.9927

RIG_SCORE: 0.5544

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S137C	TCGA-CM-6168	COAD	TCGA	PATPTPS	DEG_SCF_FBW7_1	0.1389
p.S137C	DO9602	COAD	ICGC	PATPTPS	DEG_SCF_FBW7_1	0.1389
p.S130T	DO228924	LICA	ICGC	PATPTPS	DEG_SCF_FBW7_1	0.6005
p.P134H	DO50911	LICA	ICGC	PATPTPS	DEG_SCF_FBW7_1	0.2222
p.D136Y	DO23270	LINC	ICGC	PATPTPS	DEG_SCF_FBW7_1	0.1667
p.Q135H	DO23270	LINC	ICGC	PATPTPS	DEG_SCF_FBW7_1	0.1944
p.G115R	DO229227	THCA	ICGC	PATPTPS	DEG_SCF_FBW7_1	0.0833
p.P124L	DO42304	UCEC	ICGC	PATPTPS	DEG_SCF_FBW7_1	0.6471
p.P120Q	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	PATPTPS	DEG_SCF_FBW7_1	0.2222
p.P120Q	VMRC-LCD	lung	COSMIC	PATPTPS	DEG_SCF_FBW7_1	0.2222
p.T119A	SIDM00988	Kidney Carcinoma	GDSC	PATPTPS	DEG_SCF_FBW7_1	0.1944
p.T119A	ACH-000792	Kidney Cancer	CCLE	PATPTPS	DEG_SCF_FBW7_1	0.1944
p.T119A	BFTC-909	kidney	COSMIC	PATPTPS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q674R7	Autophagy-related protein 9B	DEG_SCF_FBW7_1	124:130	PATPTPS	FBXW7	0.9689	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons