DegronMD

Uniprot ID: Q7Z7K6

Source protein: Centromere protein V

Source gene: CENPV

Class: DEG_SCF_FBW7_1

Location: 99:105

E3 ligase: FBXW7

DEGRON score: 0.9923

ASA_SCORE: 81.4857

COIL: 0.8986

CONS_SCORE: 0.2954

DSS_SCORE: 0.8465

HELIX: 0.0669

FCONS_SCORE: 1.0025

RIG_SCORE: 0.5444

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S100R	DO228952	LICA	ICGC	PATPTSS	DEG_SCF_FBW7_1	0.7427
p.F97L	DO229019	LICA	ICGC	PATPTSS	DEG_SCF_FBW7_1	0.2778
p.T98N	DO229022	LICA	ICGC	PATPTSS	DEG_SCF_FBW7_1	0.75
p.P89T	DO229037	LICA	ICGC	PATPTSS	DEG_SCF_FBW7_1	0.0556
p.M106I	DO50094	LUSC	ICGC	PATPTSS	DEG_SCF_FBW7_1	0.3056
p.R90W	DO38404	STAD	ICGC	PATPTSS	DEG_SCF_FBW7_1	0.0833
p.L106P	DO229268	THCA	ICGC	PATPTSS	DEG_SCF_FBW7_1	0.3056
p.G99V	DO42472	UCEC	ICGC	PATPTSS	DEG_SCF_FBW7_1	0.7532
p.T100M	ACH-000941	Endometrial/Uterine Cancer	CCLE	PATPTSS	DEG_SCF_FBW7_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z7K6	Centromere protein V	DEG_SCF_FBW7_1	99:105	PATPTSS	FBXW7	0.9923	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons