DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 4285:4292

E3 ligase: FBXW7

DEGRON score: 0.9855

ASA_SCORE: 86

COIL: 0.9039

CONS_SCORE: 0.2888

DSS_SCORE: 0.6483

HELIX: 0.0211

FCONS_SCORE: 1.0068

RIG_SCORE: 0.6301

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A4291V	TCGA-F1-6177	STAD	TCGA	PATTPTAT	DEG_SCF_FBW7_1	0.5825
p.A4289T	DO227844	COCA	ICGC	PATTPTAT	DEG_SCF_FBW7_1	0.7139
p.P4276S	DO50970	LICA	ICGC	PATTPTAT	DEG_SCF_FBW7_1	0.0833
p.S4302F	DO38727	STAD	ICGC	PATTPTAT	DEG_SCF_FBW7_1	0.0556
p.A4294V	DO38727	STAD	ICGC	PATTPTAT	DEG_SCF_FBW7_1	0.2778
p.T4275I	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	PATTPTAT	DEG_SCF_FBW7_1	0.0556
p.T4275I	ACH-000809	Esophageal Cancer	CCLE	PATTPTAT	DEG_SCF_FBW7_1	0.0556
p.T4275I	KYSE-410	oesophagus	COSMIC	PATTPTAT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4285:4292	PATTPTAT	FBXW7	0.9855	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons