DegronMD

Uniprot ID: Q8ND30

Source protein: Liprin-beta-2

Source gene: PPFIBP2

Class: DEG_SCF_FBW7_1

Location: 800:807

E3 ligase: FBXW7

DEGRON score: 0.9987

ASA_SCORE: 63.9

COIL: 0.8805

CONS_SCORE: 0.5174

DSS_SCORE: 0.5366

HELIX: 0.0445

FCONS_SCORE: 0.906

RIG_SCORE: 0.7315

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E792Q	TCGA-34-5240	LUSC	TCGA	PAYTPLTT	DEG_SCF_FBW7_1	0.1111
p.Y802C	TCGA-AA-A02R	COAD	TCGA	PAYTPLTT	DEG_SCF_FBW7_1	0.7087
p.P804Q	TCGA-DU-6392	LGG	TCGA	PAYTPLTT	DEG_SCF_FBW7_1	0.7035
p.E795Q	TCGA-NK-A5CR	LUSC	TCGA	PAYTPLTT	DEG_SCF_FBW7_1	0.1944
p.R812Q	SIDM00473	Oral Cavity Carcinoma	GDSC	PAYTPLTT	DEG_SCF_FBW7_1	0.1944
p.A798S	SIDM01574	Plasma Cell Myeloma	GDSC	PAYTPLTT	DEG_SCF_FBW7_1	0.2778
p.A798S	SIDM01391	Neuroblastoma	GDSC	PAYTPLTT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8ND30	Liprin-beta-2	DEG_SCF_FBW7_1	800:807	PAYTPLTT	FBXW7	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons