DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PDCTPAQT
Uniprot ID:
O60909
Source protein:
Beta-1,4-galactosyltransferase 2
Source gene:
B4GALT2
Class:
DEG_SCF_FBW7_1
Location:
137:144
E3 ligase:
FBXW7
DEGRON score:
0.8851
ASA_SCORE:
60.0125
COIL:
0.7173
CONS_SCORE:
0.5212
DSS_SCORE:
0.2901
HELIX:
0.0659
FCONS_SCORE:
0.8508
RIG_SCORE:
0.7724
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P146L
TCGA-55-A4DF
LUAD
TCGA
PDCTPAQT
DEG_SCF_FBW7_1
0.2778
p.R149W
TCGA-AX-A1C4
UCEC
TCGA
PDCTPAQT
DEG_SCF_FBW7_1
0.1944
p.R149W
SIDM00399
Head and Neck Carcinoma
GDSC
PDCTPAQT
DEG_SCF_FBW7_1
0.1944
p.R149W
SCC90
upper_aerodigestive_tract
COSMIC
PDCTPAQT
DEG_SCF_FBW7_1
0.1944
p.R149L
TCGA-FS-A1Z0
SKCM
TCGA
PDCTPAQT
DEG_SCF_FBW7_1
0.1944
p.T135I
DO231827
LINC
ICGC
PDCTPAQT
DEG_SCF_FBW7_1
0.2778
p.L138V
SIDM00651
Non-Small Cell Lung Carcinoma
GDSC
PDCTPAQT
DEG_SCF_FBW7_1
0.6765
p.L138V
NCI-H1155
lung
COSMIC
PDCTPAQT
DEG_SCF_FBW7_1
0.6765
p.T140I
ACH-000280
Ovarian Cancer
CCLE
PDCTPAQT
DEG_SCF_FBW7_1
0.7078
p.A146V
ACH-002391
Head and Neck Cancer
CCLE
PDCTPAQT
DEG_SCF_FBW7_1
0.2778
p.A146V
UDSCC2
upper_aerodigestive_tract
COSMIC
PDCTPAQT
DEG_SCF_FBW7_1
0.2778
p.L129F
SNU-175
large_intestine
COSMIC
PDCTPAQT
DEG_SCF_FBW7_1
0.1111
Drug responses associated with B4GALT2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PDCTPAQT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60909
Beta-1,4-galactosyltransferase 2
DEG_SCF_FBW7_1
137:144
PDCTPAQT
FBXW7
0.8851
More...