DegronMD

Uniprot ID: P12524

Source protein: Protein L-Myc

Source gene: MYCL

Class: DEG_SCF_FBW7_2

Location: 129:136

E3 ligase: FBXW7

DEGRON score: 0.7924

ASA_SCORE: 67.2875

COIL: 0.7924

CONS_SCORE: 0.4526

DSS_SCORE: 0.6144

HELIX: 0.1191

FCONS_SCORE: 0.9084

RIG_SCORE: 0.6296

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E133Q	TCGA-AD-A5EJ	COAD	TCGA	PDCTPSLE	DEG_SCF_FBW7_2	0.6744
p.E133Q	DO50090	COAD	ICGC	PDCTPSLE	DEG_SCF_FBW7_2	0.6744
p.S140N	TCGA-BA-5151	HNSC	TCGA	PDCTPSLE	DEG_SCF_FBW7_2	0.2222
p.S140N	DO14276	HNSC	ICGC	PDCTPSLE	DEG_SCF_FBW7_2	0.2222
p.A144S	TCGA-CD-5813	STAD	TCGA	PDCTPSLE	DEG_SCF_FBW7_2	0.1111
p.A144S	DO38259	STAD	ICGC	PDCTPSLE	DEG_SCF_FBW7_2	0.1111
p.E133K	TCGA-E6-A1LX	UCEC	TCGA	PDCTPSLE	DEG_SCF_FBW7_2	0.7022
p.E133K	TCGA-UZ-A9PS	KIRP	TCGA	PDCTPSLE	DEG_SCF_FBW7_2	0.7022
p.E133K	DO219709	KIRP	ICGC	PDCTPSLE	DEG_SCF_FBW7_2	0.7022
p.E133K	DO41020	UCEC	ICGC	PDCTPSLE	DEG_SCF_FBW7_2	0.7022
p.L143I	TCGA-EY-A1GO	UCEC	TCGA	PDCTPSLE	DEG_SCF_FBW7_2	0.1389
p.L143I	DO41392	UCEC	ICGC	PDCTPSLE	DEG_SCF_FBW7_2	0.1389
p.G128D	DO228957	LICA	ICGC	PDCTPSLE	DEG_SCF_FBW7_2	0.3056
p.P123L	LIM1215	large_intestine	COSMIC	PDCTPSLE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12524	Protein L-Myc	DEG_SCF_FBW7_2	129:136	PDCTPSLE	FBXW7	0.7924	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons