DegronMD

Uniprot ID: Q92545

Source protein: Transmembrane protein 131

Source gene: TMEM131

Class: DEG_SCF_FBW7_1

Location: 1716:1723

E3 ligase: FBXW7

DEGRON score: 0.9864

ASA_SCORE: 73.2875

COIL: 0.8128

CONS_SCORE: 0.3439

DSS_SCORE: 0.3499

HELIX: 0.1393

FCONS_SCORE: 1.009

RIG_SCORE: 0.7115

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1710I	TCGA-BR-7851	STAD	TCGA	PDFTPLNS	DEG_SCF_FBW7_1	0.1667
p.V1710I	DO38711	STAD	ICGC	PDFTPLNS	DEG_SCF_FBW7_1	0.1667
p.A1726T	TCGA-EA-A3HS	CESC	TCGA	PDFTPLNS	DEG_SCF_FBW7_1	0.25
p.A1726T	DO6260	CESC	ICGC	PDFTPLNS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92545	Transmembrane protein 131	DEG_SCF_FBW7_1	1716:1723	PDFTPLNS	FBXW7	0.9864	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons