DegronMD

Uniprot ID: Q9H1I8

Source protein: Activating signal cointegrator 1 complex subunit 2

Source gene: ASCC2

Class: DEG_SCF_FBW7_1

Location: 527:534

E3 ligase: FBXW7

DEGRON score: 0.9668

ASA_SCORE: 79.2875

COIL: 0.7868

CONS_SCORE: 0.3347

DSS_SCORE: 0.5807

HELIX: 0.146

FCONS_SCORE: 0.8012

RIG_SCORE: 0.688

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P527S	TCGA-PK-A5HB	ACC	TCGA	PDPTPLLT	DEG_SCF_FBW7_1	0.6752
p.E524D	DO6428	CLLE	ICGC	PDPTPLLT	DEG_SCF_FBW7_1	0.25
p.P529S	SIDM00935	Other Solid Cancers	GDSC	PDPTPLLT	DEG_SCF_FBW7_1	0.5641
p.P529S	SIDM00678	Bladder Carcinoma	GDSC	PDPTPLLT	DEG_SCF_FBW7_1	0.5641
p.N542D	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	PDPTPLLT	DEG_SCF_FBW7_1	0.1111
p.N542D	ACH-000757	Lung Cancer	CCLE	PDPTPLLT	DEG_SCF_FBW7_1	0.1111
p.N542D	A427	lung	COSMIC	PDPTPLLT	DEG_SCF_FBW7_1	0.1111
p.R519C	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PDPTPLLT	DEG_SCF_FBW7_1	0.1111
p.R519C	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	PDPTPLLT	DEG_SCF_FBW7_1	0.1111
p.L521R	ACH-000975	Lung Cancer	CCLE	PDPTPLLT	DEG_SCF_FBW7_1	0.1667
p.S528C	NCI-H1770	lung	COSMIC	PDPTPLLT	DEG_SCF_FBW7_1	0.7541
p.P530S	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	PDPTPLLT	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H1I8	Activating signal cointegrator 1 complex subunit 2	DEG_SCF_FBW7_1	527:534	PDPTPLLT	FBXW7	0.9668	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons