DegronMD

Uniprot ID: Q9UBG0

Source protein: C-type mannose receptor 2

Source gene: MRC2

Class: DEG_SCF_FBW7_1

Location: 659:666

E3 ligase: FBXW7

DEGRON score: 0.9009

ASA_SCORE: 81.7375

COIL: 0.9235

CONS_SCORE: 0.6295

DSS_SCORE: 0.5555

HELIX: 0.0335

FCONS_SCORE: 1.0093

RIG_SCORE: 0.6436

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A674S	TCGA-21-1077	LUSC	TCGA	PDPTPSLT	DEG_SCF_FBW7_1	0.1111
p.A674S	DO26725	LUSC	ICGC	PDPTPSLT	DEG_SCF_FBW7_1	0.1111
p.P657L	TCGA-BH-A0E6	BRCA	TCGA	PDPTPSLT	DEG_SCF_FBW7_1	0.2778
p.P657L	DO5668	BRCA	ICGC	PDPTPSLT	DEG_SCF_FBW7_1	0.2778
p.P661S	TCGA-FW-A3R5	SKCM	TCGA	PDPTPSLT	DEG_SCF_FBW7_1	0.5641
p.P661S	DO37406	SKCM	ICGC	PDPTPSLT	DEG_SCF_FBW7_1	0.5641
p.D676Y	DO229015	LICA	ICGC	PDPTPSLT	DEG_SCF_FBW7_1	0.0556
p.S668F	DO222875	MELA	ICGC	PDPTPSLT	DEG_SCF_FBW7_1	0.2778
p.S664R	DO229275	THCA	ICGC	PDPTPSLT	DEG_SCF_FBW7_1	0.6316
p.P670R	ACH-001673	Bile Duct Cancer	CCLE	PDPTPSLT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBG0	C-type mannose receptor 2	DEG_SCF_FBW7_1	659:666	PDPTPSLT	FBXW7	0.9009	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons