DegronMD

Uniprot ID: O43561

Source protein: Linker for activation of T-cells family member 1

Source gene: LAT

Class: DEG_SCF_FBW7_1

Location: 166:173

E3 ligase: FBXW7

DEGRON score: 0.9851

ASA_SCORE: 68.5

COIL: 0.8841

CONS_SCORE: 0.6573

DSS_SCORE: 0.5197

HELIX: 0.0454

FCONS_SCORE: 0.915

RIG_SCORE: 0.673

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V170L	TCGA-DF-A2KU	UCEC	TCGA	PDSTPATS	DEG_SCF_FBW7_1	0.6765
p.A178T	TCGA-EO-A22R	UCEC	TCGA	PDSTPATS	DEG_SCF_FBW7_1	0.1944
p.P165R	DO233262	GACA	ICGC	PDSTPATS	DEG_SCF_FBW7_1	0.3056
p.A176S	DO229041	LICA	ICGC	PDSTPATS	DEG_SCF_FBW7_1	0.25
p.P158L	DO222420	MELA	ICGC	PDSTPATS	DEG_SCF_FBW7_1	0.1111
p.A170T	DO42713	UCEC	ICGC	PDSTPATS	DEG_SCF_FBW7_1	0.7139
p.A156V	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PDSTPATS	DEG_SCF_FBW7_1	0.5
p.A156V	ACH-000942	Leukemia	CCLE	PDSTPATS	DEG_SCF_FBW7_1	0.5
p.P173T	ACH-001408	Bladder Cancer	CCLE	PDSTPATS	DEG_SCF_FBW7_1	0.7031
p.E179K	CRO-AP3	NS	COSMIC	PDSTPATS	DEG_SCF_FBW7_1	0.1667
p.A181V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PDSTPATS	DEG_SCF_FBW7_1	0.1111
p.E178K	CRO-AP3	NS	COSMIC	PDSTPATS	DEG_SCF_FBW7_1	0.1944
p.A180V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PDSTPATS	DEG_SCF_FBW7_1	0.1389
p.A182V	HD-MY-Z	haematopoietic_and_lymphoid_tissue	COSMIC	PDSTPATS	DEG_SCF_FBW7_1	0.0833
p.A183V	HD-MY-Z	haematopoietic_and_lymphoid_tissue	COSMIC	PDSTPATS	DEG_SCF_FBW7_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43561	Linker for activation of T-cells family member 1	DEG_SCF_FBW7_1	166:173	PDSTPATS	FBXW7	0.9851	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons