DegronMD

Uniprot ID: P13688

Source protein: Carcinoembryonic antigen-related cell adhesion molecule 1

Source gene: CEACAM1

Class: DEG_SCF_FBW7_1

Location: 237:243

E3 ligase: FBXW7

DEGRON score: 0.9386

ASA_SCORE: 58.3857

COIL: 0.7733

CONS_SCORE: 0.602

DSS_SCORE: 0.474

HELIX: 0.0231

FCONS_SCORE: 0.9919

RIG_SCORE: 0.7016

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G252E	TCGA-DA-A1IA	SKCM	TCGA	PDTPTIS	DEG_SCF_FBW7_1	0.0833
p.G252E	DO38022	SKCM	ICGC	PDTPTIS	DEG_SCF_FBW7_1	0.0833
p.G252R	TCGA-DA-A1IA	SKCM	TCGA	PDTPTIS	DEG_SCF_FBW7_1	0.0833
p.Y235C	TCGA-EO-A22X	UCEC	TCGA	PDTPTIS	DEG_SCF_FBW7_1	0.2778
p.Y235C	DO43907	UCEC	ICGC	PDTPTIS	DEG_SCF_FBW7_1	0.2778
p.R250C	TCGA-VQ-A94R	STAD	TCGA	PDTPTIS	DEG_SCF_FBW7_1	0.1389
p.R250C	DO222372	STAD	ICGC	PDTPTIS	DEG_SCF_FBW7_1	0.1389
p.T240K	DO229025	LICA	ICGC	PDTPTIS	DEG_SCF_FBW7_1	0.7306
p.T240K	DO229032	LICA	ICGC	PDTPTIS	DEG_SCF_FBW7_1	0.7306
p.T247N	DO229045	LICA	ICGC	PDTPTIS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13688	Carcinoembryonic antigen-related cell adhesion molecule 1	DEG_SCF_FBW7_1	237:243	PDTPTIS	FBXW7	0.9386	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons