DegronMD

Uniprot ID: P13667

Source protein: Protein disulfide-isomerase A4

Source gene: PDIA4

Class: DEG_SCF_FBW7_2

Location: 170:177

E3 ligase: FBXW7

DEGRON score: 0.8835

ASA_SCORE: 88.4

COIL: 0.9343

CONS_SCORE: 0.2975

DSS_SCORE: 0.3975

HELIX: 0.0399

FCONS_SCORE: 0.8113

RIG_SCORE: 0.7365

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V164A	TCGA-2W-A8YY	CESC	TCGA	PDWTPPPE	DEG_SCF_FBW7_2	0.1667
p.V164A	DO223732	CESC	ICGC	PDWTPPPE	DEG_SCF_FBW7_2	0.1667
p.S168F	TCGA-GF-A6C9	SKCM	TCGA	PDWTPPPE	DEG_SCF_FBW7_2	0.7222
p.S168F	DO51254	SKCM	ICGC	PDWTPPPE	DEG_SCF_FBW7_2	0.7222
p.V161L	TCGA-PN-A8MA	CESC	TCGA	PDWTPPPE	DEG_SCF_FBW7_2	0.0833
p.V161L	DO49982	CESC	ICGC	PDWTPPPE	DEG_SCF_FBW7_2	0.0833
p.T173M	DO229005	COCA	ICGC	PDWTPPPE	DEG_SCF_FBW7_2	0.8534
p.T173M	DO229346	LAML	ICGC	PDWTPPPE	DEG_SCF_FBW7_2	0.8534
p.T173M	DO52365	LUSC	ICGC	PDWTPPPE	DEG_SCF_FBW7_2	0.8534
p.D171N	DO233652	GACA	ICGC	PDWTPPPE	DEG_SCF_FBW7_2	0.5821
p.Q169K	DO228934	LICA	ICGC	PDWTPPPE	DEG_SCF_FBW7_2	0.3056
p.P170T	DO229035	LICA	ICGC	PDWTPPPE	DEG_SCF_FBW7_2	0.7031
p.W172C	DO23514	LIRI	ICGC	PDWTPPPE	DEG_SCF_FBW7_2	0.5889
p.V178F	SIDM01155	Glioma	GDSC	PDWTPPPE	DEG_SCF_FBW7_2	0.3056
p.V178F	ACH-000437	Brain Cancer	CCLE	PDWTPPPE	DEG_SCF_FBW7_2	0.3056
p.V178F	SW1088	central_nervous_system	COSMIC	PDWTPPPE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13667	Protein disulfide-isomerase A4	DEG_SCF_FBW7_2	170:177	PDWTPPPE	FBXW7	0.8835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons