DegronMD - P13667(PDIA4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V164A	TCGA-2W-A8YY	CESC	TCGA	PDWTPPPE	DEG_SCF_FBW7_2	170:177	Mutation rewiring degron network	0.1667
p.V164A	DO223732	CESC	ICGC	PDWTPPPE	DEG_SCF_FBW7_2	170:177	Mutation rewiring degron network	0.1667
p.D195Y	TCGA-2Z-A9J2	KIRP	TCGA	TKENF	DEG_APCC_KENBOX_2	183:187	Mutation rewiring degron network	0.1111
p.D195Y	DO219650	KIRP	ICGC	TKENF	DEG_APCC_KENBOX_2	183:187	Mutation rewiring degron network	0.1111
p.D193Y	TCGA-AP-A1DV	UCEC	TCGA	TKENF	DEG_APCC_KENBOX_2	183:187	Mutation rewiring degron network	0.1667
p.D193Y	DO43186	UCEC	ICGC	TKENF	DEG_APCC_KENBOX_2	183:187	Mutation rewiring degron network	0.1667
p.S168F	TCGA-GF-A6C9	SKCM	TCGA	PDWTPPPE	DEG_SCF_FBW7_2	170:177	Mutation blocking phosphorylation signal	0.7222
p.S168F	DO51254	SKCM	ICGC	PDWTPPPE	DEG_SCF_FBW7_2	170:177	Mutation blocking phosphorylation signal	0.7222
p.V161L	TCGA-PN-A8MA	CESC	TCGA	PDWTPPPE	DEG_SCF_FBW7_2	170:177	Mutation rewiring degron network	0.0833
p.V161L	DO49982	CESC	ICGC	PDWTPPPE	DEG_SCF_FBW7_2	170:177	Mutation rewiring degron network	0.0833
p.T173M	DO229005	COCA	ICGC	PDWTPPPE	DEG_SCF_FBW7_2	170:177	Mutation altering degron motif	0.8534
p.T173M	DO229346	LAML	ICGC	PDWTPPPE	DEG_SCF_FBW7_2	170:177	Mutation altering degron motif	0.8534
p.T173M	DO52365	LUSC	ICGC	PDWTPPPE	DEG_SCF_FBW7_2	170:177	Mutation altering degron motif	0.8534
p.D171N	DO233652	GACA	ICGC	PDWTPPPE	DEG_SCF_FBW7_2	170:177	Mutation altering degron motif	0.5821
p.Q169K	DO228934	LICA	ICGC	PDWTPPPE	DEG_SCF_FBW7_2	170:177	Mutation rewiring degron network	0.3056
p.P170T	DO229035	LICA	ICGC	PDWTPPPE	DEG_SCF_FBW7_2	170:177	Mutation altering degron motif	0.7031
p.W172C	DO23514	LIRI	ICGC	PDWTPPPE	DEG_SCF_FBW7_2	170:177	Mutation altering degron motif	0.5889
p.N192T	SIDM01307	Colorectal Carcinoma	GDSC	TKENF	DEG_APCC_KENBOX_2	183:187	Mutation rewiring degron network	0.1944
p.V178F	SIDM01155	Glioma	GDSC	TKENF	DEG_APCC_KENBOX_2	183:187	Mutation rewiring degron network	0.1944
p.V178F	SIDM01155	Glioma	GDSC	PDWTPPPE	DEG_SCF_FBW7_2	170:177	Mutation rewiring degron network	0.3056
p.V178F	ACH-000437	Brain Cancer	CCLE	TKENF	DEG_APCC_KENBOX_2	183:187	Mutation rewiring degron network	0.1944
p.V178F	ACH-000437	Brain Cancer	CCLE	PDWTPPPE	DEG_SCF_FBW7_2	170:177	Mutation rewiring degron network	0.3056
p.V178F	SW1088	central nervous system	COSMIC	TKENF	DEG_APCC_KENBOX_2	183:187	Mutation rewiring degron network	0.1944
p.V178F	SW1088	central nervous system	COSMIC	PDWTPPPE	DEG_SCF_FBW7_2	170:177	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDIA4

UniProt ID: P13667

Entrez ID: 9601

Protein name: Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDIA4 in