DegronMD

Uniprot ID: P13667

Source protein: Protein disulfide-isomerase A4

Source gene: PDIA4

Class: DEG_APCC_KENBOX_2

Location: 183:187

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.927

ASA_SCORE: 67.8

COIL: 0.3504

CONS_SCORE: 0.4986

DSS_SCORE: 0.2657

HELIX: 0.6244

FCONS_SCORE: 1.2704

RIG_SCORE: 0.8834

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D195Y	TCGA-2Z-A9J2	KIRP	TCGA	TKENF	DEG_APCC_KENBOX_2	0.1111
p.D195Y	DO219650	KIRP	ICGC	TKENF	DEG_APCC_KENBOX_2	0.1111
p.D193Y	TCGA-AP-A1DV	UCEC	TCGA	TKENF	DEG_APCC_KENBOX_2	0.1667
p.D193Y	DO43186	UCEC	ICGC	TKENF	DEG_APCC_KENBOX_2	0.1667
p.N192T	SIDM01307	Colorectal Carcinoma	GDSC	TKENF	DEG_APCC_KENBOX_2	0.1944
p.V178F	SIDM01155	Glioma	GDSC	TKENF	DEG_APCC_KENBOX_2	0.1944
p.V178F	ACH-000437	Brain Cancer	CCLE	TKENF	DEG_APCC_KENBOX_2	0.1944
p.V178F	SW1088	central_nervous_system	COSMIC	TKENF	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13667	Protein disulfide-isomerase A4	DEG_APCC_KENBOX_2	183:187	TKENF	APC,CDC20,FZR1	0.927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons