DegronMD

Uniprot ID: Q9Y5G6

Source protein: Protocadherin gamma-A7

Source gene: PCDHGA7

Class: DEG_SCF_FBW7_1

Location: 357:364

E3 ligase: FBXW7

DEGRON score: 0.6039

ASA_SCORE: 58.1375

COIL: 0.8383

CONS_SCORE: 0.601

DSS_SCORE: 0.2598

HELIX: 0.0308

FCONS_SCORE: 1.0146

RIG_SCORE: 0.7675

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D359G	TCGA-06-5416	GBM	TCGA	PEDTPLGT	DEG_SCF_FBW7_1	0.6087
p.D359G	DO10880	GBM	ICGC	PEDTPLGT	DEG_SCF_FBW7_1	0.6087
p.Q372R	TCGA-17-Z045	LUAD	TCGA	PEDTPLGT	DEG_SCF_FBW7_1	0.1111
p.P361S	TCGA-18-3409	LUSC	TCGA	PEDTPLGT	DEG_SCF_FBW7_1	0.6752
p.P361S	DO26444	LUSC	ICGC	PEDTPLGT	DEG_SCF_FBW7_1	0.6752
p.I356V	TCGA-A8-A08R	BRCA	TCGA	PEDTPLGT	DEG_SCF_FBW7_1	0.3056
p.I356V	DO1255	BRCA	ICGC	PEDTPLGT	DEG_SCF_FBW7_1	0.3056
p.A367D	TCGA-AX-A06F	UCEC	TCGA	PEDTPLGT	DEG_SCF_FBW7_1	0.25
p.A367D	DO41752	UCEC	ICGC	PEDTPLGT	DEG_SCF_FBW7_1	0.25
p.S353G	TCGA-CG-4441	STAD	TCGA	PEDTPLGT	DEG_SCF_FBW7_1	0.2222
p.S353G	DO38250	STAD	ICGC	PEDTPLGT	DEG_SCF_FBW7_1	0.2222
p.P357H	TCGA-D3-A2JC	SKCM	TCGA	PEDTPLGT	DEG_SCF_FBW7_1	0.7694
p.P357H	DO47578	SKCM	ICGC	PEDTPLGT	DEG_SCF_FBW7_1	0.7694
p.P357S	TCGA-EE-A2A6	SKCM	TCGA	PEDTPLGT	DEG_SCF_FBW7_1	0.6752
p.P357S	DO37591	SKCM	ICGC	PEDTPLGT	DEG_SCF_FBW7_1	0.6752
p.P357L	TCGA-EE-A2A6	SKCM	TCGA	PEDTPLGT	DEG_SCF_FBW7_1	0.6471
p.P357L	DO37591	SKCM	ICGC	PEDTPLGT	DEG_SCF_FBW7_1	0.6471
p.D359N	TCGA-G2-A3VY	BLCA	TCGA	PEDTPLGT	DEG_SCF_FBW7_1	0.5821
p.D359N	DO590	BLCA	ICGC	PEDTPLGT	DEG_SCF_FBW7_1	0.5821
p.M349I	DO227609	COCA	ICGC	PEDTPLGT	DEG_SCF_FBW7_1	0.1111
p.T364K	DO228511	MALY	ICGC	PEDTPLGT	DEG_SCF_FBW7_1	0.7306
p.T350M	SIDM00660	Colorectal Carcinoma	GDSC	PEDTPLGT	DEG_SCF_FBW7_1	0.1389
p.T350M	SIDM00836	Colorectal Carcinoma	GDSC	PEDTPLGT	DEG_SCF_FBW7_1	0.1389
p.T350M	ACH-000820	Colon/Colorectal Cancer	CCLE	PEDTPLGT	DEG_SCF_FBW7_1	0.1389
p.T350M	ACH-000985	Colon/Colorectal Cancer	CCLE	PEDTPLGT	DEG_SCF_FBW7_1	0.1389
p.T350M	SW403	large_intestine	COSMIC	PEDTPLGT	DEG_SCF_FBW7_1	0.1389
p.T350M	LS-411N	large_intestine	COSMIC	PEDTPLGT	DEG_SCF_FBW7_1	0.1389
p.S355L	SIDM01608	Endometrial Carcinoma	GDSC	PEDTPLGT	DEG_SCF_FBW7_1	0.2778
p.S355L	ACH-000990	Endometrial/Uterine Cancer	CCLE	PEDTPLGT	DEG_SCF_FBW7_1	0.2778
p.P361A	SIDM01378	Ovarian Carcinoma	GDSC	PEDTPLGT	DEG_SCF_FBW7_1	0.7503
p.P361A	ACH-000646	Ovarian Cancer	CCLE	PEDTPLGT	DEG_SCF_FBW7_1	0.7503
p.V365F	SIDM01378	Ovarian Carcinoma	GDSC	PEDTPLGT	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PEDTPLGT

Degron related mutations and impact score

Drug responses associated with PCDHGA7 mutations

All proteins holding degron of PEDTPLGT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5G6	Protocadherin gamma-A7	DEG_SCF_FBW7_1	357:364	PEDTPLGT	FBXW7	0.6039	More...