DegronMD - Q9Y5G6(PCDHGA7)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D359G	TCGA-06-5416	GBM	TCGA	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation altering degron motif	0.6087
p.D359G	DO10880	GBM	ICGC	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation altering degron motif	0.6087
p.Q372R	TCGA-17-Z045	LUAD	TCGA	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.1111
p.P361S	TCGA-18-3409	LUSC	TCGA	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation altering degron motif	0.6752
p.P361S	DO26444	LUSC	ICGC	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation altering degron motif	0.6752
p.V795I	TCGA-A6-2686	COAD	TCGA	CKENL	DEG_APCC_KENBOX_2	800:804	Mutation rewiring degron network	0.1944
p.V795I	DO7828	COAD	ICGC	CKENL	DEG_APCC_KENBOX_2	800:804	Mutation rewiring degron network	0.1944
p.V795I	SIDM00217	Colorectal Carcinoma	GDSC	CKENL	DEG_APCC_KENBOX_2	800:804	Mutation rewiring degron network	0.1944
p.V795I	ACH-000999	Colon/Colorectal Cancer	CCLE	CKENL	DEG_APCC_KENBOX_2	800:804	Mutation rewiring degron network	0.1944
p.V795I	SNU-1040	large intestine	COSMIC	CKENL	DEG_APCC_KENBOX_2	800:804	Mutation rewiring degron network	0.1944
p.I356V	TCGA-A8-A08R	BRCA	TCGA	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.3056
p.I356V	DO1255	BRCA	ICGC	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.3056
p.S790Y	TCGA-AP-A056	UCEC	TCGA	CKENL	DEG_APCC_KENBOX_2	800:804	Mutation rewiring degron network	0.0556
p.S790Y	TCGA-EO-A3B0	UCEC	TCGA	CKENL	DEG_APCC_KENBOX_2	800:804	Mutation rewiring degron network	0.0556
p.S790Y	DO219773	UCEC	ICGC	CKENL	DEG_APCC_KENBOX_2	800:804	Mutation rewiring degron network	0.0556
p.S790Y	DO43971	UCEC	ICGC	CKENL	DEG_APCC_KENBOX_2	800:804	Mutation rewiring degron network	0.0556
p.D796E	TCGA-AX-A05Z	UCEC	TCGA	CKENL	DEG_APCC_KENBOX_2	800:804	Mutation rewiring degron network	0.2222
p.D796E	DO40884	UCEC	ICGC	CKENL	DEG_APCC_KENBOX_2	800:804	Mutation rewiring degron network	0.2222
p.A367D	TCGA-AX-A06F	UCEC	TCGA	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.25
p.A367D	DO41752	UCEC	ICGC	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.25
p.S353G	TCGA-CG-4441	STAD	TCGA	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.2222
p.S353G	DO38250	STAD	ICGC	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.2222
p.C800Y	TCGA-D1-A103	UCEC	TCGA	CKENL	DEG_APCC_KENBOX_2	800:804	Mutation altering degron motif	0.5976
p.C800Y	DO42312	UCEC	ICGC	CKENL	DEG_APCC_KENBOX_2	800:804	Mutation altering degron motif	0.5976
p.P357H	TCGA-D3-A2JC	SKCM	TCGA	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation altering degron motif	0.7694
p.P357H	DO47578	SKCM	ICGC	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation altering degron motif	0.7694
p.P357S	TCGA-EE-A2A6	SKCM	TCGA	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation altering degron motif	0.6752
p.P357S	DO37591	SKCM	ICGC	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation altering degron motif	0.6752
p.P357L	TCGA-EE-A2A6	SKCM	TCGA	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation altering degron motif	0.6471
p.P357L	DO37591	SKCM	ICGC	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation altering degron motif	0.6471
p.D359N	TCGA-G2-A3VY	BLCA	TCGA	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation altering degron motif	0.5821
p.D359N	DO590	BLCA	ICGC	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation altering degron motif	0.5821
p.T793I	TCGA-NJ-A55A	LUAD	TCGA	CKENL	DEG_APCC_KENBOX_2	800:804	Mutation rewiring degron network	0.1389
p.T793I	DO218945	LUAD	ICGC	CKENL	DEG_APCC_KENBOX_2	800:804	Mutation rewiring degron network	0.1389
p.M349I	DO227609	COCA	ICGC	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.1111
p.D796N	DO50454	ESAD	ICGC	CKENL	DEG_APCC_KENBOX_2	800:804	Mutation rewiring degron network	0.2222
p.T364K	DO228511	MALY	ICGC	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation altering degron motif	0.7306
p.E802K	DO222653	MELA	ICGC	CKENL	DEG_APCC_KENBOX_2	800:804	Mutation altering degron motif	0.7022
p.Q808K	DO218180	ORCA	ICGC	CKENL	DEG_APCC_KENBOX_2	800:804	Mutation rewiring degron network	0.2222
p.P805S	DO46327	OV	ICGC	CKENL	DEG_APCC_KENBOX_2	800:804	Mutation rewiring degron network	0.3056
p.T350M	SIDM00660	Colorectal Carcinoma	GDSC	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.1389
p.T350M	SIDM00836	Colorectal Carcinoma	GDSC	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.1389
p.T350M	ACH-000820	Colon/Colorectal Cancer	CCLE	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.1389
p.T350M	ACH-000985	Colon/Colorectal Cancer	CCLE	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.1389
p.T350M	SW403	large intestine	COSMIC	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.1389
p.T350M	LS-411N	large intestine	COSMIC	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.1389
p.L792Q	SIDM01503	Small Cell Lung Carcinoma	GDSC	CKENL	DEG_APCC_KENBOX_2	800:804	Mutation rewiring degron network	0.1111
p.L792Q	ACH-000844	Lung Cancer	CCLE	CKENL	DEG_APCC_KENBOX_2	800:804	Mutation rewiring degron network	0.1111
p.S355L	SIDM01608	Endometrial Carcinoma	GDSC	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.2778
p.S355L	ACH-000990	Endometrial/Uterine Cancer	CCLE	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.2778
p.P361A	SIDM01378	Ovarian Carcinoma	GDSC	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation altering degron motif	0.7503
p.P361A	ACH-000646	Ovarian Cancer	CCLE	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation altering degron motif	0.7503
p.V365F	SIDM01378	Ovarian Carcinoma	GDSC	PEDTPLGT	DEG_SCF_FBW7_1	357:364	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDHGA7

UniProt ID: Q9Y5G6

Entrez ID: 56108

Protein name: Protocadherin gamma-A7 (PCDH-gamma-A7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCDHGA7 in