DegronMD

Uniprot ID: Q9Y5G6

Source protein: Protocadherin gamma-A7

Source gene: PCDHGA7

Class: DEG_APCC_KENBOX_2

Location: 800:804

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9722

ASA_SCORE: 84.68

COIL: 0.6826

CONS_SCORE: 0.5327

DSS_SCORE: 0.5026

HELIX: 0.2802

FCONS_SCORE: 1.0499

RIG_SCORE: 0.767

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V795I	TCGA-A6-2686	COAD	TCGA	CKENL	DEG_APCC_KENBOX_2	0.1944
p.V795I	DO7828	COAD	ICGC	CKENL	DEG_APCC_KENBOX_2	0.1944
p.V795I	SIDM00217	Colorectal Carcinoma	GDSC	CKENL	DEG_APCC_KENBOX_2	0.1944
p.V795I	ACH-000999	Colon/Colorectal Cancer	CCLE	CKENL	DEG_APCC_KENBOX_2	0.1944
p.V795I	SNU-1040	large_intestine	COSMIC	CKENL	DEG_APCC_KENBOX_2	0.1944
p.S790Y	TCGA-AP-A056	UCEC	TCGA	CKENL	DEG_APCC_KENBOX_2	0.0556
p.S790Y	TCGA-EO-A3B0	UCEC	TCGA	CKENL	DEG_APCC_KENBOX_2	0.0556
p.S790Y	DO219773	UCEC	ICGC	CKENL	DEG_APCC_KENBOX_2	0.0556
p.S790Y	DO43971	UCEC	ICGC	CKENL	DEG_APCC_KENBOX_2	0.0556
p.D796E	TCGA-AX-A05Z	UCEC	TCGA	CKENL	DEG_APCC_KENBOX_2	0.2222
p.D796E	DO40884	UCEC	ICGC	CKENL	DEG_APCC_KENBOX_2	0.2222
p.C800Y	TCGA-D1-A103	UCEC	TCGA	CKENL	DEG_APCC_KENBOX_2	0.5976
p.C800Y	DO42312	UCEC	ICGC	CKENL	DEG_APCC_KENBOX_2	0.5976
p.T793I	TCGA-NJ-A55A	LUAD	TCGA	CKENL	DEG_APCC_KENBOX_2	0.1389
p.T793I	DO218945	LUAD	ICGC	CKENL	DEG_APCC_KENBOX_2	0.1389
p.D796N	DO50454	ESAD	ICGC	CKENL	DEG_APCC_KENBOX_2	0.2222
p.E802K	DO222653	MELA	ICGC	CKENL	DEG_APCC_KENBOX_2	0.7022
p.Q808K	DO218180	ORCA	ICGC	CKENL	DEG_APCC_KENBOX_2	0.2222
p.P805S	DO46327	OV	ICGC	CKENL	DEG_APCC_KENBOX_2	0.3056
p.L792Q	SIDM01503	Small Cell Lung Carcinoma	GDSC	CKENL	DEG_APCC_KENBOX_2	0.1111
p.L792Q	ACH-000844	Lung Cancer	CCLE	CKENL	DEG_APCC_KENBOX_2	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons