DegronMD

Uniprot ID: Q00534

Source protein: Cyclin-dependent kinase 6

Source gene: CDK6

Class: DEG_APCC_KENBOX_2

Location: 306:310

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9121

ASA_SCORE: 89.64

COIL: 0.761

CONS_SCORE: 0.2806

DSS_SCORE: 0.4648

HELIX: 0.2046

FCONS_SCORE: 0.6654

RIG_SCORE: 0.7195

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T320I	TCGA-85-8355	LUSC	TCGA	CKENL	DEG_APCC_KENBOX_2	0.0556
p.T320I	DO45488	LUSC	ICGC	CKENL	DEG_APCC_KENBOX_2	0.0556
p.D302G	TCGA-B5-A3FA	UCEC	TCGA	CKENL	DEG_APCC_KENBOX_2	0.2222
p.D302G	DO52402	UCEC	ICGC	CKENL	DEG_APCC_KENBOX_2	0.2222
p.E308K	DO222939	BTCA	ICGC	CKENL	DEG_APCC_KENBOX_2	0.7022
p.P316S	DO233281	GACA	ICGC	CKENL	DEG_APCC_KENBOX_2	0.1667
p.R305K	DO222527	MELA	ICGC	CKENL	DEG_APCC_KENBOX_2	0.3056
p.C306Y	DO229245	THCA	ICGC	CKENL	DEG_APCC_KENBOX_2	0.5976
p.H313Y	SIDM00527	Colorectal Carcinoma	GDSC	CKENL	DEG_APCC_KENBOX_2	0.25
p.H313Y	ACH-000935	Colon/Colorectal Cancer	CCLE	CKENL	DEG_APCC_KENBOX_2	0.25
p.H313Y	MDST8	large_intestine	COSMIC	CKENL	DEG_APCC_KENBOX_2	0.25

Drug responses associated with CDK6 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00951	LAML\|acute_myeloid_leukaemia	p.L33V (No)	GDSC	AT-7519	0.1165
SIDM00951	LAML\|acute_myeloid_leukaemia	p.L33V (No)	GDSC	Palbociclib	1.7828
SIDM00951	LAML\|acute_myeloid_leukaemia	p.L33V (No)	GDSC	Palbociclib	2.7949
SIDM00213	THCA\|thyroid	p.R168H (No)	GDSC	AT-7519	150.7509
SIDM00213	THCA\|thyroid	p.R168H (No)	GDSC	Palbociclib	14.6971
SIDM00213	THCA\|thyroid	p.R168H (No)	GDSC	Palbociclib	481.55
SIDM00680	COREAD\|large_intestine	p.R144H (No)	GDSC	AT-7519	1.0871
SIDM00680	COREAD\|large_intestine	p.R144H (No)	GDSC	Palbociclib	2.6004
SIDM00680	COREAD\|large_intestine	p.R144H (No)	GDSC	Palbociclib	5.4741
SIDM00151	OV\|ovary	p.T121A (No)	GDSC	Palbociclib	2.8144
SIDM00151	OV\|ovary	p.T121A (No)	GDSC	Palbociclib	4.2957
SIDM00145	ALL\|lymphoblastic_leukemia	p.R220C (No)	GDSC	AT-7519	0.2394
SIDM00145	ALL\|lymphoblastic_leukemia	p.R220C (No)	GDSC	Palbociclib	0.2745
SIDM00145	ALL\|lymphoblastic_leukemia	p.R220C (No)	GDSC	Palbociclib	11.931
SIDM00527	COREAD\|large_intestine	p.H313Y (Yes)	GDSC	AT-7519	10.6683
SIDM00527	COREAD\|large_intestine	p.H313Y (Yes)	GDSC	Palbociclib	5.6718
SIDM00527	COREAD\|large_intestine	p.H313Y (Yes)	GDSC	Palbociclib	9.8542
SIDM01007	ALL\|lymphoblastic_leukemia	p.W243* (No)	GDSC	AT-7519	0.0972
SIDM01007	ALL\|lymphoblastic_leukemia	p.W243* (No)	GDSC	Palbociclib	0.388
SIDM01007	ALL\|lymphoblastic_leukemia	p.W243* (No)	GDSC	Palbociclib	3.2029
SIDM00516	SKCM\|melanoma	p.P199L (No)	GDSC	AT-7519	0.8509
SIDM00516	SKCM\|melanoma	p.P199L (No)	GDSC	Palbociclib	19.4726
SIDM00506	SCLC\|lung_small_cell_carcinoma	p.T88S (No)	GDSC	AT-7519	1.8835
SIDM00506	SCLC\|lung_small_cell_carcinoma	p.T88S (No)	GDSC	Palbociclib	92.9994
SIDM00506	SCLC\|lung_small_cell_carcinoma	p.T88S (No)	GDSC	Palbociclib	168.09
SIDM00280	UNCLASSIFIED\|stomach	p.V190I (No)	GDSC	AT-7519	1.9002
SIDM00280	UNCLASSIFIED\|stomach	p.V190I (No)	GDSC	Palbociclib	5.9839
SIDM00280	UNCLASSIFIED\|stomach	p.V190I (No)	GDSC	Palbociclib	48.499
SIDM00125	KIRC\|kidney	p.S317C (Yes)	GDSC	AT-7519	0.7495
SIDM00125	KIRC\|kidney	p.S317C (Yes)	GDSC	Palbociclib	1.31
SIDM00125	KIRC\|kidney	p.S317C (Yes)	GDSC	Palbociclib	9.8115
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.H139Q (No)	GDSC	AT-7519	8.4199
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.H139Q (No)	GDSC	Palbociclib	59.902
SIDM00096	UNCLASSIFIED\|lymphoid_neoplasm_other	p.S317C (Yes)	GDSC	AT-7519	0.1339
SIDM00096	UNCLASSIFIED\|lymphoid_neoplasm_other	p.S317C (Yes)	GDSC	Palbociclib	1.3461
SIDM00096	UNCLASSIFIED\|lymphoid_neoplasm_other	p.S317C (Yes)	GDSC	Palbociclib	0.819
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.D246E (No)	GDSC	AT-7519	2.201
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.D246E (No)	GDSC	Palbociclib	60.1013
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.D246E (No)	GDSC	Palbociclib	37.222
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.S317C (Yes)	GDSC	AT-7519	0.5575
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.S317C (Yes)	GDSC	Palbociclib	6.8312
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.S317C (Yes)	GDSC	Palbociclib	23.941
SIDM00934	PAAD\|pancreas	p.S317C (Yes)	GDSC	AT-7519	0.9007
SIDM00934	PAAD\|pancreas	p.S317C (Yes)	GDSC	Palbociclib	18.0731
SIDM00934	PAAD\|pancreas	p.S317C (Yes)	GDSC	Palbociclib	95.061
SIDM00562	BRCA\|breast	p.D275H (No)	GDSC	AT-7519	28.9074
SIDM00562	BRCA\|breast	p.D275H (No)	GDSC	Palbociclib	18.5067
SIDM00562	BRCA\|breast	p.D275H (No)	GDSC	Palbociclib	7.5307
SIDM00562	BRCA\|breast	p.D275H (No)	GDSC	Ribociclib	17.485

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q00534	Cyclin-dependent kinase 6	DEG_APCC_KENBOX_2	306:310	CKENL	APC,CDC20,FZR1	0.9121	More...
Q9Y5G6	Protocadherin gamma-A7	DEG_APCC_KENBOX_2	800:804	CKENL	APC,CDC20,FZR1	0.9722	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: CKENL

Degron related mutations and impact score

Drug responses associated with CDK6 mutations

All proteins holding degron of CKENL