DegronMD

Uniprot ID: Q9H819

Source protein: DnaJ homolog subfamily C member 18

Source gene: DNAJC18

Class: DEG_SCF_FBW7_1

Location: 25:32

E3 ligase: FBXW7

DEGRON score: 0.7063

ASA_SCORE: 103.3

COIL: 0.9498

CONS_SCORE: 0.3106

DSS_SCORE: 0.396

HELIX: 0.0395

FCONS_SCORE: 1.0359

RIG_SCORE: 0.6246

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A18T	TCGA-A5-A0G2	UCEC	TCGA	PEDTPPES	DEG_SCF_FBW7_1	0.1389
p.A18T	DO41235	UCEC	ICGC	PEDTPPES	DEG_SCF_FBW7_1	0.1389
p.D27G	TCGA-CK-5913	COAD	TCGA	PEDTPPES	DEG_SCF_FBW7_1	0.6087
p.D27G	DO8826	COAD	ICGC	PEDTPPES	DEG_SCF_FBW7_1	0.6087
p.R20K	TCGA-CN-4734	HNSC	TCGA	PEDTPPES	DEG_SCF_FBW7_1	0.1944
p.R20K	DO15446	HNSC	ICGC	PEDTPPES	DEG_SCF_FBW7_1	0.1944
p.E31A	DO228261	LICA	ICGC	PEDTPPES	DEG_SCF_FBW7_1	0.659
p.A18E	DO229036	LICA	ICGC	PEDTPPES	DEG_SCF_FBW7_1	0.1389
p.E31D	DO229242	THCA	ICGC	PEDTPPES	DEG_SCF_FBW7_1	0.5647
p.H33N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PEDTPPES	DEG_SCF_FBW7_1	0.3056
p.H33N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PEDTPPES	DEG_SCF_FBW7_1	0.3056
p.M42I	SIDM00529	Breast Carcinoma	GDSC	PEDTPPES	DEG_SCF_FBW7_1	0.0556
p.M42I	MDA-MB-157	breast	COSMIC	PEDTPPES	DEG_SCF_FBW7_1	0.0556
p.M42T	SIDM00154	Mesothelioma	GDSC	PEDTPPES	DEG_SCF_FBW7_1	0.0556
p.M42T	ACH-002130	Lung Cancer	CCLE	PEDTPPES	DEG_SCF_FBW7_1	0.0556
p.M42T	H2795	pleura	COSMIC	PEDTPPES	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H819	DnaJ homolog subfamily C member 18	DEG_SCF_FBW7_1	25:32	PEDTPPES	FBXW7	0.7063	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons