DegronMD

Uniprot ID: Q6V0I7

Source protein: Protocadherin Fat 4

Source gene: FAT4

Class: DEG_SCF_FBW7_1

Location: 2060:2067

E3 ligase: FBXW7

DEGRON score: 0.8071

ASA_SCORE: 60.9875

COIL: 0.7884

CONS_SCORE: 0.6196

DSS_SCORE: 0.2765

HELIX: 0.0115

FCONS_SCORE: 1.0574

RIG_SCORE: 0.7958

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2063K	TCGA-AA-3976	COAD	TCGA	PENTPIDT	DEG_SCF_FBW7_1	0.7306
p.P2077T	TCGA-AA-A01V	COAD	TCGA	PENTPIDT	DEG_SCF_FBW7_1	0.0556
p.P2077R	TCGA-AA-A01V	COAD	TCGA	PENTPIDT	DEG_SCF_FBW7_1	0.0556
p.Y2058N	TCGA-AH-6897	READ	TCGA	PENTPIDT	DEG_SCF_FBW7_1	0.2778
p.P2060S	TCGA-D3-A8GI	SKCM	TCGA	PENTPIDT	DEG_SCF_FBW7_1	0.6752
p.E2061D	TCGA-EO-A3B0	UCEC	TCGA	PENTPIDT	DEG_SCF_FBW7_1	0.5647
p.S2053F	TCGA-ZF-AA4V	BLCA	TCGA	PENTPIDT	DEG_SCF_FBW7_1	0.1389
p.L2060P	DO222652	BTCA	ICGC	PENTPIDT	DEG_SCF_FBW7_1	0.7582
p.R2066Q	DO52717	CLLE	ICGC	PENTPIDT	DEG_SCF_FBW7_1	0.7329
p.R2066Q	DO9772	COAD	ICGC	PENTPIDT	DEG_SCF_FBW7_1	0.7329
p.A2063V	DO51734	COAD	ICGC	PENTPIDT	DEG_SCF_FBW7_1	0.6936
p.L2060R	DO222709	COCA	ICGC	PENTPIDT	DEG_SCF_FBW7_1	0.8428
p.L2060R	DO51763	STAD	ICGC	PENTPIDT	DEG_SCF_FBW7_1	0.8428
p.V2077I	DO223058	ESCA	ICGC	PENTPIDT	DEG_SCF_FBW7_1	0.0556
p.V2077I	DO42057	UCEC	ICGC	PENTPIDT	DEG_SCF_FBW7_1	0.0556
p.V2072L	DO229027	LICA	ICGC	PENTPIDT	DEG_SCF_FBW7_1	0.1944
p.E2053K	DO222504	MELA	ICGC	PENTPIDT	DEG_SCF_FBW7_1	0.1389
p.A2062S	DO220011	SARC	ICGC	PENTPIDT	DEG_SCF_FBW7_1	0.7588
p.P2074S	DO47419	SKCM	ICGC	PENTPIDT	DEG_SCF_FBW7_1	0.1389
p.P2074S	DO219487	SKCM	ICGC	PENTPIDT	DEG_SCF_FBW7_1	0.1389
p.P2074S	HCC2998	large_intestine	COSMIC	PENTPIDT	DEG_SCF_FBW7_1	0.1389
p.A2051T	DO43306	UCEC	ICGC	PENTPIDT	DEG_SCF_FBW7_1	0.0833
p.T2058M	DO43186	UCEC	ICGC	PENTPIDT	DEG_SCF_FBW7_1	0.2778
p.R2057I	DO43154	UCEC	ICGC	PENTPIDT	DEG_SCF_FBW7_1	0.25
p.H2068N	DO43923	UCEC	ICGC	PENTPIDT	DEG_SCF_FBW7_1	0.3056
p.P2064H	SIDM00113	Kidney Carcinoma	GDSC	PENTPIDT	DEG_SCF_FBW7_1	0.7694
p.P2064H	ACH-001208	Kidney Cancer	CCLE	PENTPIDT	DEG_SCF_FBW7_1	0.7694
p.P2064H	TK10	kidney	COSMIC	PENTPIDT	DEG_SCF_FBW7_1	0.7694
p.L2052I	SIDM01611	Endometrial Carcinoma	GDSC	PENTPIDT	DEG_SCF_FBW7_1	0.1111
p.L2052I	ACH-000996	Endometrial/Uterine Cancer	CCLE	PENTPIDT	DEG_SCF_FBW7_1	0.1111
p.K2071R	SIDM01561	Melanoma	GDSC	PENTPIDT	DEG_SCF_FBW7_1	0.3333
p.K2071R	ACH-000799	Skin Cancer	CCLE	PENTPIDT	DEG_SCF_FBW7_1	0.3333

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PENTPIDT

Degron related mutations and impact score

Drug responses associated with FAT4 mutations

All proteins holding degron of PENTPIDT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6V0I7	Protocadherin Fat 4	DEG_SCF_FBW7_1	2060:2067	PENTPIDT	FBXW7	0.8071	More...