DegronMD

Uniprot ID: E9PAV3

Source protein: Nascent polypeptide-associated complex subunit alpha, muscle-specific form

Source gene: NACA

Class: DEG_SCF_FBW7_1

Location: 1690:1697

E3 ligase: FBXW7

DEGRON score: 0.9883

ASA_SCORE: 97.9375

COIL: 0.9504

CONS_SCORE: 0.5305

DSS_SCORE: 0.592

HELIX: 0.0128

FCONS_SCORE: 1.2694

RIG_SCORE: 0.7016

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1698D	DO229041	LICA	ICGC	PESTPIIT	DEG_SCF_FBW7_1	0.3056
p.T1693M	DO50103	LUSC	ICGC	PESTPIIT	DEG_SCF_FBW7_1	0.7423
p.T1693M	DO41638	UCEC	ICGC	PESTPIIT	DEG_SCF_FBW7_1	0.7423
p.P1704L	DO37786	SKCM	ICGC	PESTPIIT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1690:1697	PESTPIIT	FBXW7	0.9883	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons