DegronMD

Uniprot ID: A8MVS5

Source protein: Protein HIDE1

Source gene: HIDE1

Class: DEG_SCF_FBW7_1

Location: 218:224

E3 ligase: FBXW7

DEGRON score: 0.8034

ASA_SCORE: 61.0857

COIL: 0.6271

CONS_SCORE: 0.6248

DSS_SCORE: 0.7392

HELIX: 0.0244

FCONS_SCORE: 1.0465

RIG_SCORE: 0.6485

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E219Q	TCGA-AX-A2IO	UCEC	TCGA	PETPEFS	DEG_SCF_FBW7_1	0.5633
p.E219Q	DO40800	UCEC	ICGC	PETPEFS	DEG_SCF_FBW7_1	0.5633
p.E222K	TCGA-EI-6917	READ	TCGA	PETPEFS	DEG_SCF_FBW7_1	0.591
p.E222K	DO36881	READ	ICGC	PETPEFS	DEG_SCF_FBW7_1	0.591
p.F226L	TCGA-FX-A3NK	SARC	TCGA	PETPEFS	DEG_SCF_FBW7_1	0.2778
p.F226L	DO220120	SARC	ICGC	PETPEFS	DEG_SCF_FBW7_1	0.2778
p.R208Q	DO233260	GACA	ICGC	PETPEFS	DEG_SCF_FBW7_1	0.0556
p.R208Q	DO222775	MELA	ICGC	PETPEFS	DEG_SCF_FBW7_1	0.0556
p.C229F	DO229035	LICA	ICGC	PETPEFS	DEG_SCF_FBW7_1	0.1944
p.S217L	DO231343	THCA	ICGC	PETPEFS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MVS5	Protein HIDE1	DEG_SCF_FBW7_1	218:224	PETPEFS	FBXW7	0.8034	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons