DegronMD

Uniprot ID: Q96DU7

Source protein: Inositol-trisphosphate 3-kinase C

Source gene: ITPKC

Class: DEG_SCF_FBW7_2

Location: 334:340

E3 ligase: FBXW7

DEGRON score: 0.9849

ASA_SCORE: 99.1714

COIL: 0.907

CONS_SCORE: 0.371

DSS_SCORE: 0.6381

HELIX: 0.0524

FCONS_SCORE: 0.9958

RIG_SCORE: 0.6831

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E335K	TCGA-13-1496	OV	TCGA	PETPEPE	DEG_SCF_FBW7_2	0.591
p.E335K	DO31899	OV	ICGC	PETPEPE	DEG_SCF_FBW7_2	0.591
p.I331N	TCGA-D3-A2JH	SKCM	TCGA	PETPEPE	DEG_SCF_FBW7_2	0.25
p.I331N	DO47263	SKCM	ICGC	PETPEPE	DEG_SCF_FBW7_2	0.25
p.A341V	TCGA-VQ-A922	STAD	TCGA	PETPEPE	DEG_SCF_FBW7_2	0.3056
p.A341V	DO51794	STAD	ICGC	PETPEPE	DEG_SCF_FBW7_2	0.3056
p.E335D	TCGA-VS-A953	CESC	TCGA	PETPEPE	DEG_SCF_FBW7_2	0.5647
p.E335D	DO219727	CESC	ICGC	PETPEPE	DEG_SCF_FBW7_2	0.5647
p.A341S	DO229037	LICA	ICGC	PETPEPE	DEG_SCF_FBW7_2	0.3056
p.P337S	DO232761	PBCA	ICGC	PETPEPE	DEG_SCF_FBW7_2	0.6752
p.P334L	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PETPEPE	DEG_SCF_FBW7_2	0.6471
p.P334L	ACH-001738	Leukemia	CCLE	PETPEPE	DEG_SCF_FBW7_2	0.6471
p.P334L	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PETPEPE	DEG_SCF_FBW7_2	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96DU7	Inositol-trisphosphate 3-kinase C	DEG_SCF_FBW7_2	334:340	PETPEPE	FBXW7	0.9849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons