DegronMD

Uniprot ID: Q9BZA7

Source protein: Protocadherin-11 X-linked

Source gene: PCDH11X

Class: DEG_SCF_FBW7_1

Location: 952:958

E3 ligase: FBXW7

DEGRON score: 0.9905

ASA_SCORE: 86.7857

COIL: 0.8479

CONS_SCORE: 0.6093

DSS_SCORE: 0.565

HELIX: 0.1119

FCONS_SCORE: 1.0259

RIG_SCORE: 0.6645

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N957H	TCGA-22-5492	LUSC	TCGA	PETPLNS	DEG_SCF_FBW7_1	0.6312
p.N957H	DO27208	LUSC	ICGC	PETPLNS	DEG_SCF_FBW7_1	0.6312
p.Q964K	TCGA-73-4670	LUAD	TCGA	PETPLNS	DEG_SCF_FBW7_1	0.1667
p.Q964K	DO25350	LUAD	ICGC	PETPLNS	DEG_SCF_FBW7_1	0.1667
p.F948Y	TCGA-78-7155	LUAD	TCGA	PETPLNS	DEG_SCF_FBW7_1	0.2222
p.F948Y	DO23590	LUAD	ICGC	PETPLNS	DEG_SCF_FBW7_1	0.2222
p.L966P	TCGA-AA-A010	COAD	TCGA	PETPLNS	DEG_SCF_FBW7_1	0.1111
p.Q964H	TCGA-BR-8384	STAD	TCGA	PETPLNS	DEG_SCF_FBW7_1	0.1667
p.Q964H	DO47749	STAD	ICGC	PETPLNS	DEG_SCF_FBW7_1	0.1667
p.A942D	TCGA-CN-4739	HNSC	TCGA	PETPLNS	DEG_SCF_FBW7_1	0.0556
p.A942D	DO14478	HNSC	ICGC	PETPLNS	DEG_SCF_FBW7_1	0.0556
p.P967S	DO222798	COCA	ICGC	PETPLNS	DEG_SCF_FBW7_1	0.0833
p.P955S	DO231868	LINC	ICGC	PETPLNS	DEG_SCF_FBW7_1	0.6752
p.A942S	DO48736	LIRI	ICGC	PETPLNS	DEG_SCF_FBW7_1	0.0556
p.A947T	DO23518	LIRI	ICGC	PETPLNS	DEG_SCF_FBW7_1	0.1944
p.Q949K	DO52670	MALY	ICGC	PETPLNS	DEG_SCF_FBW7_1	0.25
p.Q951E	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	PETPLNS	DEG_SCF_FBW7_1	0.3056
p.Q951E	ACH-001233	Lung Cancer	CCLE	PETPLNS	DEG_SCF_FBW7_1	0.3056
p.Q951E	VMRC-LCD	lung	COSMIC	PETPLNS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BZA7	Protocadherin-11 X-linked	DEG_SCF_FBW7_1	952:958	PETPLNS	FBXW7	0.9905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons