DegronMD - Q9BZA7(PCDH11X)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R787S	TCGA-17-Z015	LUAD	TCGA	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.1667
p.N957H	TCGA-22-5492	LUSC	TCGA	PETPLNS	DEG_SCF_FBW7_1	952:958	Mutation altering degron motif	0.6312
p.N957H	DO27208	LUSC	ICGC	PETPLNS	DEG_SCF_FBW7_1	952:958	Mutation altering degron motif	0.6312
p.S804Y	TCGA-34-5234	LUSC	TCGA	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.1944
p.S804Y	DO26810	LUSC	ICGC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.1944
p.Q964K	TCGA-73-4670	LUAD	TCGA	PETPLNS	DEG_SCF_FBW7_1	952:958	Mutation rewiring degron network	0.1667
p.Q964K	DO25350	LUAD	ICGC	PETPLNS	DEG_SCF_FBW7_1	952:958	Mutation rewiring degron network	0.1667
p.F948Y	TCGA-78-7155	LUAD	TCGA	PETPLNS	DEG_SCF_FBW7_1	952:958	Mutation rewiring degron network	0.2222
p.F948Y	DO23590	LUAD	ICGC	PETPLNS	DEG_SCF_FBW7_1	952:958	Mutation rewiring degron network	0.2222
p.L966P	TCGA-AA-A010	COAD	TCGA	PETPLNS	DEG_SCF_FBW7_1	952:958	Mutation rewiring degron network	0.1111
p.R787C	TCGA-AP-A0LM	UCEC	TCGA	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.1667
p.R787C	DO222421	BTCA	ICGC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.1667
p.R787C	DO43306	UCEC	ICGC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.1667
p.R787C	SIDM00837	Colorectal Carcinoma	GDSC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.1667
p.R787C	ACH-000958	Colon/Colorectal Cancer	CCLE	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.1667
p.R787C	SW48	large intestine	COSMIC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.1667
p.S789N	TCGA-AP-A1DV	UCEC	TCGA	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.2222
p.S789N	DO43186	UCEC	ICGC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.2222
p.R787H	TCGA-AX-A05Z	UCEC	TCGA	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.1667
p.R787H	DO52456	COCA	ICGC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.1667
p.R787H	DO40884	UCEC	ICGC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.1667
p.A792T	TCGA-B4-5835	KIRC	TCGA	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.3056
p.A792T	DO17562	KIRC	ICGC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.3056
p.Q964H	TCGA-BR-8384	STAD	TCGA	PETPLNS	DEG_SCF_FBW7_1	952:958	Mutation rewiring degron network	0.1667
p.Q964H	DO47749	STAD	ICGC	PETPLNS	DEG_SCF_FBW7_1	952:958	Mutation rewiring degron network	0.1667
p.A942D	TCGA-CN-4739	HNSC	TCGA	PETPLNS	DEG_SCF_FBW7_1	952:958	Mutation rewiring degron network	0.0556
p.A942D	DO14478	HNSC	ICGC	PETPLNS	DEG_SCF_FBW7_1	952:958	Mutation rewiring degron network	0.0556
p.D809N	TCGA-CV-A6JE	HNSC	TCGA	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.0556
p.D809N	DO49046	HNSC	ICGC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.0556
p.P796T	TCGA-F9-A4JJ	KIRP	TCGA	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation altering degron motif	0.7031
p.P796T	DO48472	KIRP	ICGC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation altering degron motif	0.7031
p.P796Q	TCGA-G4-6320	COAD	TCGA	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation altering degron motif	0.7035
p.P796Q	DO8159	COAD	ICGC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation altering degron motif	0.7035
p.V794A	TCGA-HU-A4H4	STAD	TCGA	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation altering degron motif	0.5825
p.V794A	DO47721	STAD	ICGC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation altering degron motif	0.5825
p.V794A	SIDM00216	Colorectal Carcinoma	GDSC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation altering degron motif	0.5825
p.V794A	ACH-000989	Colon/Colorectal Cancer	CCLE	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation altering degron motif	0.5825
p.V794A	SNU-175	large intestine	COSMIC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation altering degron motif	0.5825
p.P967S	DO222798	COCA	ICGC	PETPLNS	DEG_SCF_FBW7_1	952:958	Mutation rewiring degron network	0.0833
p.V803E	DO233913	GACA	ICGC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.2222
p.P955S	DO231868	LINC	ICGC	PETPLNS	DEG_SCF_FBW7_1	952:958	Mutation altering degron motif	0.6752
p.A942S	DO48736	LIRI	ICGC	PETPLNS	DEG_SCF_FBW7_1	952:958	Mutation rewiring degron network	0.0556
p.A947T	DO23518	LIRI	ICGC	PETPLNS	DEG_SCF_FBW7_1	952:958	Mutation rewiring degron network	0.1944
p.D802Y	DO231031	LUSC	ICGC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.25
p.Q949K	DO52670	MALY	ICGC	PETPLNS	DEG_SCF_FBW7_1	952:958	Mutation rewiring degron network	0.25
p.T790S	SIDM00525	Osteosarcoma	GDSC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.25
p.T790S	ACH-000359	Bone Cancer	CCLE	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.25
p.T790S	MG-63	bone	COSMIC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.25
p.Q951E	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	PETPLNS	DEG_SCF_FBW7_1	952:958	Mutation rewiring degron network	0.3056
p.Q951E	ACH-001233	Lung Cancer	CCLE	PETPLNS	DEG_SCF_FBW7_1	952:958	Mutation rewiring degron network	0.3056
p.Q951E	VMRC-LCD	lung	COSMIC	PETPLNS	DEG_SCF_FBW7_1	952:958	Mutation rewiring degron network	0.3056
p.D809Y	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.0556
p.D809Y	ACH-000886	Lung Cancer	CCLE	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.0556
p.D809Y	NCI-H2009	lung	COSMIC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.0556
p.P793T	SIDM00006	Other Solid Cancers	GDSC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation altering degron motif	0.7031
p.P793T	ACH-001552	Skin Cancer	CCLE	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation altering degron motif	0.7031
p.P793T	MCC26	skin	COSMIC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation altering degron motif	0.7031
p.E784K	ACH-002396	Bone Cancer	CCLE	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.0833
p.E784K	Sarc9371	bone	COSMIC	PVTPNTE	DEG_SCF_FBW7_2	793:799	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDH11X

UniProt ID: Q9BZA7

Entrez ID: 27328

Protein name: Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) (Protocadherin-S)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PCDH11X in