DegronMD

Uniprot ID: Q9BZA7

Source protein: Protocadherin-11 X-linked

Source gene: PCDH11X

Class: DEG_SCF_FBW7_2

Location: 793:799

E3 ligase: FBXW7

DEGRON score: 0.9049

ASA_SCORE: 80.3429

COIL: 0.91

CONS_SCORE: 0.5889

DSS_SCORE: 0.407

HELIX: 0.037

FCONS_SCORE: 1.0434

RIG_SCORE: 0.7566

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R787S	TCGA-17-Z015	LUAD	TCGA	PVTPNTE	DEG_SCF_FBW7_2	0.1667
p.S804Y	TCGA-34-5234	LUSC	TCGA	PVTPNTE	DEG_SCF_FBW7_2	0.1944
p.S804Y	DO26810	LUSC	ICGC	PVTPNTE	DEG_SCF_FBW7_2	0.1944
p.R787C	TCGA-AP-A0LM	UCEC	TCGA	PVTPNTE	DEG_SCF_FBW7_2	0.1667
p.R787C	DO222421	BTCA	ICGC	PVTPNTE	DEG_SCF_FBW7_2	0.1667
p.R787C	DO43306	UCEC	ICGC	PVTPNTE	DEG_SCF_FBW7_2	0.1667
p.R787C	SIDM00837	Colorectal Carcinoma	GDSC	PVTPNTE	DEG_SCF_FBW7_2	0.1667
p.R787C	ACH-000958	Colon/Colorectal Cancer	CCLE	PVTPNTE	DEG_SCF_FBW7_2	0.1667
p.R787C	SW48	large_intestine	COSMIC	PVTPNTE	DEG_SCF_FBW7_2	0.1667
p.S789N	TCGA-AP-A1DV	UCEC	TCGA	PVTPNTE	DEG_SCF_FBW7_2	0.2222
p.S789N	DO43186	UCEC	ICGC	PVTPNTE	DEG_SCF_FBW7_2	0.2222
p.R787H	TCGA-AX-A05Z	UCEC	TCGA	PVTPNTE	DEG_SCF_FBW7_2	0.1667
p.R787H	DO52456	COCA	ICGC	PVTPNTE	DEG_SCF_FBW7_2	0.1667
p.R787H	DO40884	UCEC	ICGC	PVTPNTE	DEG_SCF_FBW7_2	0.1667
p.A792T	TCGA-B4-5835	KIRC	TCGA	PVTPNTE	DEG_SCF_FBW7_2	0.3056
p.A792T	DO17562	KIRC	ICGC	PVTPNTE	DEG_SCF_FBW7_2	0.3056
p.D809N	TCGA-CV-A6JE	HNSC	TCGA	PVTPNTE	DEG_SCF_FBW7_2	0.0556
p.D809N	DO49046	HNSC	ICGC	PVTPNTE	DEG_SCF_FBW7_2	0.0556
p.P796T	TCGA-F9-A4JJ	KIRP	TCGA	PVTPNTE	DEG_SCF_FBW7_2	0.7031
p.P796T	DO48472	KIRP	ICGC	PVTPNTE	DEG_SCF_FBW7_2	0.7031
p.P796Q	TCGA-G4-6320	COAD	TCGA	PVTPNTE	DEG_SCF_FBW7_2	0.7035
p.P796Q	DO8159	COAD	ICGC	PVTPNTE	DEG_SCF_FBW7_2	0.7035
p.V794A	TCGA-HU-A4H4	STAD	TCGA	PVTPNTE	DEG_SCF_FBW7_2	0.5825
p.V794A	DO47721	STAD	ICGC	PVTPNTE	DEG_SCF_FBW7_2	0.5825
p.V794A	SIDM00216	Colorectal Carcinoma	GDSC	PVTPNTE	DEG_SCF_FBW7_2	0.5825
p.V794A	ACH-000989	Colon/Colorectal Cancer	CCLE	PVTPNTE	DEG_SCF_FBW7_2	0.5825
p.V794A	SNU-175	large_intestine	COSMIC	PVTPNTE	DEG_SCF_FBW7_2	0.5825
p.V803E	DO233913	GACA	ICGC	PVTPNTE	DEG_SCF_FBW7_2	0.2222
p.D802Y	DO231031	LUSC	ICGC	PVTPNTE	DEG_SCF_FBW7_2	0.25
p.T790S	SIDM00525	Osteosarcoma	GDSC	PVTPNTE	DEG_SCF_FBW7_2	0.25
p.T790S	ACH-000359	Bone Cancer	CCLE	PVTPNTE	DEG_SCF_FBW7_2	0.25
p.T790S	MG-63	bone	COSMIC	PVTPNTE	DEG_SCF_FBW7_2	0.25
p.D809Y	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	PVTPNTE	DEG_SCF_FBW7_2	0.0556
p.D809Y	ACH-000886	Lung Cancer	CCLE	PVTPNTE	DEG_SCF_FBW7_2	0.0556
p.D809Y	NCI-H2009	lung	COSMIC	PVTPNTE	DEG_SCF_FBW7_2	0.0556
p.P793T	SIDM00006	Other Solid Cancers	GDSC	PVTPNTE	DEG_SCF_FBW7_2	0.7031
p.P793T	ACH-001552	Skin Cancer	CCLE	PVTPNTE	DEG_SCF_FBW7_2	0.7031
p.P793T	MCC26	skin	COSMIC	PVTPNTE	DEG_SCF_FBW7_2	0.7031
p.E784K	ACH-002396	Bone Cancer	CCLE	PVTPNTE	DEG_SCF_FBW7_2	0.0833
p.E784K	Sarc9371	bone	COSMIC	PVTPNTE	DEG_SCF_FBW7_2	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTPNTE

Degron related mutations and impact score

Drug responses associated with PCDH11X mutations

All proteins holding degron of PVTPNTE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BZA7	Protocadherin-11 X-linked	DEG_SCF_FBW7_2	793:799	PVTPNTE	FBXW7	0.9049	More...