DegronMD

Uniprot ID: Q5VWG9

Source protein: Transcription initiation factor TFIID subunit 3

Source gene: TAF3

Class: DEG_SCF_FBW7_1

Location: 337:343

E3 ligase: FBXW7

DEGRON score: 0.9981

ASA_SCORE: 109.4857

COIL: 0.9704

CONS_SCORE: 0.369

DSS_SCORE: 0.7679

HELIX: 0.0147

FCONS_SCORE: 1.0856

RIG_SCORE: 0.6168

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V335L	TCGA-91-8499	LUAD	TCGA	PETPNRT	DEG_SCF_FBW7_1	0.2778
p.V335L	DO45349	LUAD	ICGC	PETPNRT	DEG_SCF_FBW7_1	0.2778
p.H329R	TCGA-AX-A0J1	UCEC	TCGA	PETPNRT	DEG_SCF_FBW7_1	0.1111
p.H329R	DO41199	UCEC	ICGC	PETPNRT	DEG_SCF_FBW7_1	0.1111
p.T339M	TCGA-DM-A1HB	COAD	TCGA	PETPNRT	DEG_SCF_FBW7_1	0.8534
p.E350K	TCGA-XF-A9SY	BLCA	TCGA	PETPNRT	DEG_SCF_FBW7_1	0.1389
p.E350K	DO51918	BLCA	ICGC	PETPNRT	DEG_SCF_FBW7_1	0.1389
p.S349T	DO234285	ESAD	ICGC	PETPNRT	DEG_SCF_FBW7_1	0.6111
p.P331L	DO220857	MELA	ICGC	PETPNRT	DEG_SCF_FBW7_1	0.1667
p.I330F	SIDM01099	Neuroblastoma	GDSC	PETPNRT	DEG_SCF_FBW7_1	0.1389
p.I330F	SIDM00878	Breast Carcinoma	GDSC	PETPNRT	DEG_SCF_FBW7_1	0.1389
p.I330F	SIDM00971	Breast Carcinoma	GDSC	PETPNRT	DEG_SCF_FBW7_1	0.1389
p.I330F	SIDM00032	Bladder Carcinoma	GDSC	PETPNRT	DEG_SCF_FBW7_1	0.1389
p.I330F	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PETPNRT	DEG_SCF_FBW7_1	0.1389
p.I330F	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PETPNRT	DEG_SCF_FBW7_1	0.1389
p.I330F	SIDM00257	Neuroblastoma	GDSC	PETPNRT	DEG_SCF_FBW7_1	0.1389
p.T327M	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PETPNRT	DEG_SCF_FBW7_1	0.0556
p.T327M	ACH-000937	Leukemia	CCLE	PETPNRT	DEG_SCF_FBW7_1	0.0556
p.T327M	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PETPNRT	DEG_SCF_FBW7_1	0.0556
p.L348V	ACH-001303	Neuroblastoma	CCLE	PETPNRT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VWG9	Transcription initiation factor TFIID subunit 3	DEG_SCF_FBW7_1	337:343	PETPNRT	FBXW7	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons