DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PETPPFS
Uniprot ID:
A6NNM3
Source protein:
RIMS-binding protein 3B
Source gene:
RIMBP3B
Class:
DEG_SCF_FBW7_1
Location:
1192:1198
E3 ligase:
FBXW7
DEGRON score:
0.6552
ASA_SCORE:
80.3714
COIL:
0.9393
CONS_SCORE:
0.4163
DSS_SCORE:
0.1995
HELIX:
0.0197
FCONS_SCORE:
1.0405
RIG_SCORE:
0.7478
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with RIMBP3B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PETPPFS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UFD9
RIMS-binding protein 3A
DEG_SCF_FBW7_1
1192:1198
PETPPFS
FBXW7
0.5088
More...
A6NJZ7
RIMS-binding protein 3C
DEG_SCF_FBW7_1
1192:1198
PETPPFS
FBXW7
0.6552
More...
A6NNM3
RIMS-binding protein 3B
DEG_SCF_FBW7_1
1192:1198
PETPPFS
FBXW7
0.6552
More...