DegronMD

Uniprot ID: Q9UFD9

Source protein: RIMS-binding protein 3A

Source gene: RIMBP3

Class: DEG_SCF_FBW7_1

Location: 1192:1198

E3 ligase: FBXW7

DEGRON score: 0.5088

ASA_SCORE: 78.6

COIL: 0.9364

CONS_SCORE: 0.3832

DSS_SCORE: 0.1995

HELIX: 0.0217

FCONS_SCORE: 1.0488

RIG_SCORE: 0.7478

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1183K	TCGA-EO-A3B0	UCEC	TCGA	PETPPFS	DEG_SCF_FBW7_1	0.0833
p.E1183K	DO219773	UCEC	ICGC	PETPPFS	DEG_SCF_FBW7_1	0.0833
p.H1189Y	TCGA-Q1-A73O	CESC	TCGA	PETPPFS	DEG_SCF_FBW7_1	0.25
p.H1189Y	DO51612	CESC	ICGC	PETPPFS	DEG_SCF_FBW7_1	0.25
p.D1184Y	DO229024	LICA	ICGC	PETPPFS	DEG_SCF_FBW7_1	0.1111
p.D1184Y	ACH-000166	Leukemia	CCLE	PETPPFS	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons