DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PETPQDS
Uniprot ID:
Q641Q2
Source protein:
WASH complex subunit 2A
Source gene:
WASHC2A
Class:
DEG_SCF_FBW7_1
Location:
933:939
E3 ligase:
FBXW7
DEGRON score:
0.9495
ASA_SCORE:
94.0429
COIL:
0.9076
CONS_SCORE:
0.4143
DSS_SCORE:
0.6509
HELIX:
0.0567
FCONS_SCORE:
1.2193
RIG_SCORE:
0.6602
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E949K
SIDM00606
Squamous Cell Lung Carcinoma
GDSC
PETPQDS
DEG_SCF_FBW7_1
0.0556
Drug responses associated with WASHC2A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PETPQDS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q641Q2
WASH complex subunit 2A
DEG_SCF_FBW7_1
933:939
PETPQDS
FBXW7
0.9495
More...