DegronMD

Uniprot ID: P35523

Source protein: Chloride channel protein 1

Source gene: CLCN1

Class: DEG_SCF_FBW7_1

Location: 927:933

E3 ligase: FBXW7

DEGRON score: 0.9711

ASA_SCORE: 89.7714

COIL: 0.9586

CONS_SCORE: 0.2777

DSS_SCORE: 0.7642

HELIX: 0.0091

FCONS_SCORE: 0.9946

RIG_SCORE: 0.5616

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G918A	TCGA-99-8025	LUAD	TCGA	PETPVPS	DEG_SCF_FBW7_1	0.0833
p.G918A	DO24255	LUAD	ICGC	PETPVPS	DEG_SCF_FBW7_1	0.0833
p.P932L	TCGA-BF-AAP4	SKCM	TCGA	PETPVPS	DEG_SCF_FBW7_1	0.6471
p.P932L	TCGA-FS-A1ZW	SKCM	TCGA	PETPVPS	DEG_SCF_FBW7_1	0.6471
p.P932L	DO37519	SKCM	ICGC	PETPVPS	DEG_SCF_FBW7_1	0.6471
p.P932L	DO219468	SKCM	ICGC	PETPVPS	DEG_SCF_FBW7_1	0.6471
p.G918E	TCGA-D3-A2J8	SKCM	TCGA	PETPVPS	DEG_SCF_FBW7_1	0.0833
p.G918E	DO37778	SKCM	ICGC	PETPVPS	DEG_SCF_FBW7_1	0.0833
p.P930T	TCGA-D3-A3C6	SKCM	TCGA	PETPVPS	DEG_SCF_FBW7_1	0.7031
p.P930T	DO37507	SKCM	ICGC	PETPVPS	DEG_SCF_FBW7_1	0.7031
p.E928D	TCGA-E6-A1M0	UCEC	TCGA	PETPVPS	DEG_SCF_FBW7_1	0.5647
p.E928D	DO43682	UCEC	ICGC	PETPVPS	DEG_SCF_FBW7_1	0.5647
p.E928D	SIDM00118	Colorectal Carcinoma	GDSC	PETPVPS	DEG_SCF_FBW7_1	0.5647
p.E928D	ACH-001081	Colon/Colorectal Cancer	CCLE	PETPVPS	DEG_SCF_FBW7_1	0.5647
p.E928D	HCC2998	large_intestine	COSMIC	PETPVPS	DEG_SCF_FBW7_1	0.5647
p.S941F	TCGA-EE-A2GI	SKCM	TCGA	PETPVPS	DEG_SCF_FBW7_1	0.1111
p.S941F	DO222595	MELA	ICGC	PETPVPS	DEG_SCF_FBW7_1	0.1111
p.S941F	DO37410	SKCM	ICGC	PETPVPS	DEG_SCF_FBW7_1	0.1111
p.P936S	TCGA-FR-A726	SKCM	TCGA	PETPVPS	DEG_SCF_FBW7_1	0.25
p.P936S	TCGA-W3-A824	SKCM	TCGA	PETPVPS	DEG_SCF_FBW7_1	0.25
p.P936S	DO48665	SKCM	ICGC	PETPVPS	DEG_SCF_FBW7_1	0.25
p.P936S	DO51271	SKCM	ICGC	PETPVPS	DEG_SCF_FBW7_1	0.25
p.P936S	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	PETPVPS	DEG_SCF_FBW7_1	0.25
p.P936S	ACH-001642	Lymphoma	CCLE	PETPVPS	DEG_SCF_FBW7_1	0.25
p.P936S	SCC-3	haematopoietic_and_lymphoid_tissue	COSMIC	PETPVPS	DEG_SCF_FBW7_1	0.25
p.P939L	TCGA-FW-A3R5	SKCM	TCGA	PETPVPS	DEG_SCF_FBW7_1	0.1667
p.P939L	DO37406	SKCM	ICGC	PETPVPS	DEG_SCF_FBW7_1	0.1667
p.S935F	TCGA-YD-A9TA	SKCM	TCGA	PETPVPS	DEG_SCF_FBW7_1	0.2778
p.S935F	DO229453	SKCA	ICGC	PETPVPS	DEG_SCF_FBW7_1	0.2778
p.S935F	DO219503	SKCM	ICGC	PETPVPS	DEG_SCF_FBW7_1	0.2778
p.S933F	DO229456	SKCA	ICGC	PETPVPS	DEG_SCF_FBW7_1	0.7982
p.D921G	SIDM00135	Breast Carcinoma	GDSC	PETPVPS	DEG_SCF_FBW7_1	0.1667
p.D921G	ACH-000148	Breast Cancer	CCLE	PETPVPS	DEG_SCF_FBW7_1	0.1667
p.D921G	Hs-578-T	breast	COSMIC	PETPVPS	DEG_SCF_FBW7_1	0.1667
p.T929N	ACH-002446	Gastric Cancer	CCLE	PETPVPS	DEG_SCF_FBW7_1	0.8166

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PETPVPS

Degron related mutations and impact score

Drug responses associated with CLCN1 mutations

All proteins holding degron of PETPVPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35523	Chloride channel protein 1	DEG_SCF_FBW7_1	927:933	PETPVPS	FBXW7	0.9711	More...