DegronMD - P35523(CLCN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G918A	TCGA-99-8025	LUAD	TCGA	SPETPVPSP	DEG_COP1_1	926:934	Mutation rewiring degron network	0.1111
p.G918A	TCGA-99-8025	LUAD	TCGA	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation rewiring degron network	0.0833
p.G918A	DO24255	LUAD	ICGC	SPETPVPSP	DEG_COP1_1	926:934	Mutation rewiring degron network	0.1111
p.G918A	DO24255	LUAD	ICGC	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation rewiring degron network	0.0833
p.P932L	TCGA-BF-AAP4	SKCM	TCGA	SPETPVPSP	DEG_COP1_1	926:934	Mutation altering degron motif	0.7582
p.P932L	TCGA-BF-AAP4	SKCM	TCGA	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation altering degron motif	0.6471
p.P932L	TCGA-FS-A1ZW	SKCM	TCGA	SPETPVPSP	DEG_COP1_1	926:934	Mutation altering degron motif	0.7582
p.P932L	TCGA-FS-A1ZW	SKCM	TCGA	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation altering degron motif	0.6471
p.P932L	DO37519	SKCM	ICGC	SPETPVPSP	DEG_COP1_1	926:934	Mutation altering degron motif	0.7582
p.P932L	DO37519	SKCM	ICGC	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation altering degron motif	0.6471
p.P932L	DO219468	SKCM	ICGC	SPETPVPSP	DEG_COP1_1	926:934	Mutation altering degron motif	0.7582
p.P932L	DO219468	SKCM	ICGC	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation altering degron motif	0.6471
p.G918E	TCGA-D3-A2J8	SKCM	TCGA	SPETPVPSP	DEG_COP1_1	926:934	Mutation rewiring degron network	0.1111
p.G918E	TCGA-D3-A2J8	SKCM	TCGA	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation rewiring degron network	0.0833
p.G918E	DO37778	SKCM	ICGC	SPETPVPSP	DEG_COP1_1	926:934	Mutation rewiring degron network	0.1111
p.G918E	DO37778	SKCM	ICGC	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation rewiring degron network	0.0833
p.P930T	TCGA-D3-A3C6	SKCM	TCGA	SPETPVPSP	DEG_COP1_1	926:934	Mutation altering degron motif	0.5919
p.P930T	TCGA-D3-A3C6	SKCM	TCGA	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation altering degron motif	0.7031
p.P930T	DO37507	SKCM	ICGC	SPETPVPSP	DEG_COP1_1	926:934	Mutation altering degron motif	0.5919
p.P930T	DO37507	SKCM	ICGC	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation altering degron motif	0.7031
p.E928D	TCGA-E6-A1M0	UCEC	TCGA	SPETPVPSP	DEG_COP1_1	926:934	Mutation altering degron motif	0.5647
p.E928D	TCGA-E6-A1M0	UCEC	TCGA	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation altering degron motif	0.5647
p.E928D	DO43682	UCEC	ICGC	SPETPVPSP	DEG_COP1_1	926:934	Mutation altering degron motif	0.5647
p.E928D	DO43682	UCEC	ICGC	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation altering degron motif	0.5647
p.E928D	SIDM00118	Colorectal Carcinoma	GDSC	SPETPVPSP	DEG_COP1_1	926:934	Mutation altering degron motif	0.5647
p.E928D	SIDM00118	Colorectal Carcinoma	GDSC	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation altering degron motif	0.5647
p.E928D	ACH-001081	Colon/Colorectal Cancer	CCLE	SPETPVPSP	DEG_COP1_1	926:934	Mutation altering degron motif	0.5647
p.E928D	ACH-001081	Colon/Colorectal Cancer	CCLE	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation altering degron motif	0.5647
p.E928D	HCC2998	large intestine	COSMIC	SPETPVPSP	DEG_COP1_1	926:934	Mutation altering degron motif	0.5647
p.E928D	HCC2998	large intestine	COSMIC	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation altering degron motif	0.5647
p.S941F	TCGA-EE-A2GI	SKCM	TCGA	SPETPVPSP	DEG_COP1_1	926:934	Mutation rewiring degron network	0.1389
p.S941F	TCGA-EE-A2GI	SKCM	TCGA	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation rewiring degron network	0.1111
p.S941F	DO222595	MELA	ICGC	SPETPVPSP	DEG_COP1_1	926:934	Mutation rewiring degron network	0.1389
p.S941F	DO222595	MELA	ICGC	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation rewiring degron network	0.1111
p.S941F	DO37410	SKCM	ICGC	SPETPVPSP	DEG_COP1_1	926:934	Mutation rewiring degron network	0.1389
p.S941F	DO37410	SKCM	ICGC	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation rewiring degron network	0.1111
p.P936S	TCGA-FR-A726	SKCM	TCGA	SPETPVPSP	DEG_COP1_1	926:934	Mutation rewiring degron network	0.2778
p.P936S	TCGA-FR-A726	SKCM	TCGA	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation rewiring degron network	0.25
p.P936S	TCGA-W3-A824	SKCM	TCGA	SPETPVPSP	DEG_COP1_1	926:934	Mutation rewiring degron network	0.2778
p.P936S	TCGA-W3-A824	SKCM	TCGA	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation rewiring degron network	0.25
p.P936S	DO48665	SKCM	ICGC	SPETPVPSP	DEG_COP1_1	926:934	Mutation rewiring degron network	0.2778
p.P936S	DO48665	SKCM	ICGC	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation rewiring degron network	0.25
p.P936S	DO51271	SKCM	ICGC	SPETPVPSP	DEG_COP1_1	926:934	Mutation rewiring degron network	0.2778
p.P936S	DO51271	SKCM	ICGC	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation rewiring degron network	0.25
p.P936S	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	SPETPVPSP	DEG_COP1_1	926:934	Mutation rewiring degron network	0.2778
p.P936S	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation rewiring degron network	0.25
p.P936S	ACH-001642	Lymphoma	CCLE	SPETPVPSP	DEG_COP1_1	926:934	Mutation rewiring degron network	0.2778
p.P936S	ACH-001642	Lymphoma	CCLE	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation rewiring degron network	0.25
p.P936S	SCC-3	haematopoietic and lymphoid tissue	COSMIC	SPETPVPSP	DEG_COP1_1	926:934	Mutation rewiring degron network	0.2778
p.P936S	SCC-3	haematopoietic and lymphoid tissue	COSMIC	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation rewiring degron network	0.25
p.P939L	TCGA-FW-A3R5	SKCM	TCGA	SPETPVPSP	DEG_COP1_1	926:934	Mutation rewiring degron network	0.1944
p.P939L	TCGA-FW-A3R5	SKCM	TCGA	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation rewiring degron network	0.1667
p.P939L	DO37406	SKCM	ICGC	SPETPVPSP	DEG_COP1_1	926:934	Mutation rewiring degron network	0.1944
p.P939L	DO37406	SKCM	ICGC	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation rewiring degron network	0.1667
p.S935F	TCGA-YD-A9TA	SKCM	TCGA	SPETPVPSP	DEG_COP1_1	926:934	Mutation rewiring degron network	0.3056
p.S935F	TCGA-YD-A9TA	SKCM	TCGA	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation rewiring degron network	0.2778
p.S935F	DO229453	SKCA	ICGC	SPETPVPSP	DEG_COP1_1	926:934	Mutation rewiring degron network	0.3056
p.S935F	DO229453	SKCA	ICGC	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation rewiring degron network	0.2778
p.S935F	DO219503	SKCM	ICGC	SPETPVPSP	DEG_COP1_1	926:934	Mutation rewiring degron network	0.3056
p.S935F	DO219503	SKCM	ICGC	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation rewiring degron network	0.2778
p.S933F	DO229456	SKCA	ICGC	SPETPVPSP	DEG_COP1_1	926:934	Mutation altering degron motif	0.7982
p.S933F	DO229456	SKCA	ICGC	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation altering degron motif	0.7982
p.D921G	SIDM00135	Breast Carcinoma	GDSC	SPETPVPSP	DEG_COP1_1	926:934	Mutation rewiring degron network	0.1944
p.D921G	SIDM00135	Breast Carcinoma	GDSC	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation rewiring degron network	0.1667
p.D921G	ACH-000148	Breast Cancer	CCLE	SPETPVPSP	DEG_COP1_1	926:934	Mutation rewiring degron network	0.1944
p.D921G	ACH-000148	Breast Cancer	CCLE	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation rewiring degron network	0.1667
p.D921G	Hs-578-T	breast	COSMIC	SPETPVPSP	DEG_COP1_1	926:934	Mutation rewiring degron network	0.1944
p.D921G	Hs-578-T	breast	COSMIC	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation rewiring degron network	0.1667
p.P934S	SIDM00003	Melanoma	GDSC	SPETPVPSP	DEG_COP1_1	926:934	Mutation altering degron motif	0.6752
p.P934S	ACH-002159	Skin Cancer	CCLE	SPETPVPSP	DEG_COP1_1	926:934	Mutation altering degron motif	0.6752
p.P934S	M14	skin	COSMIC	SPETPVPSP	DEG_COP1_1	926:934	Mutation altering degron motif	0.6752
p.A916V	ACH-001853	Bile Duct Cancer	CCLE	SPETPVPSP	DEG_COP1_1	926:934	Mutation rewiring degron network	0.0556
p.T929N	ACH-002446	Gastric Cancer	CCLE	SPETPVPSP	DEG_COP1_1	926:934	Mutation altering degron motif	0.7055
p.T929N	ACH-002446	Gastric Cancer	CCLE	PETPVPS	DEG_SCF_FBW7_1	927:933	Mutation altering degron motif	0.8166

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLCN1

UniProt ID: P35523

Entrez ID: 1180

Protein name: Chloride channel protein 1 (ClC-1) (Chloride channel protein, skeletal muscle)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLCN1 in