DegronMD

Uniprot ID: P35523

Source protein: Chloride channel protein 1

Source gene: CLCN1

Class: DEG_COP1_1

Location: 926:934

E3 ligase: COP1

DEGRON score: 0.9812

ASA_SCORE: 88.1889

COIL: 0.9583

CONS_SCORE: 0.2814

DSS_SCORE: 0.7633

HELIX: 0.0103

FCONS_SCORE: 1.0118

RIG_SCORE: 0.5628

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G918A	TCGA-99-8025	LUAD	TCGA	SPETPVPSP	DEG_COP1_1	0.1111
p.G918A	DO24255	LUAD	ICGC	SPETPVPSP	DEG_COP1_1	0.1111
p.P932L	TCGA-BF-AAP4	SKCM	TCGA	SPETPVPSP	DEG_COP1_1	0.7582
p.P932L	TCGA-FS-A1ZW	SKCM	TCGA	SPETPVPSP	DEG_COP1_1	0.7582
p.P932L	DO37519	SKCM	ICGC	SPETPVPSP	DEG_COP1_1	0.7582
p.P932L	DO219468	SKCM	ICGC	SPETPVPSP	DEG_COP1_1	0.7582
p.G918E	TCGA-D3-A2J8	SKCM	TCGA	SPETPVPSP	DEG_COP1_1	0.1111
p.G918E	DO37778	SKCM	ICGC	SPETPVPSP	DEG_COP1_1	0.1111
p.P930T	TCGA-D3-A3C6	SKCM	TCGA	SPETPVPSP	DEG_COP1_1	0.5919
p.P930T	DO37507	SKCM	ICGC	SPETPVPSP	DEG_COP1_1	0.5919
p.E928D	TCGA-E6-A1M0	UCEC	TCGA	SPETPVPSP	DEG_COP1_1	0.5647
p.E928D	DO43682	UCEC	ICGC	SPETPVPSP	DEG_COP1_1	0.5647
p.E928D	SIDM00118	Colorectal Carcinoma	GDSC	SPETPVPSP	DEG_COP1_1	0.5647
p.E928D	ACH-001081	Colon/Colorectal Cancer	CCLE	SPETPVPSP	DEG_COP1_1	0.5647
p.E928D	HCC2998	large_intestine	COSMIC	SPETPVPSP	DEG_COP1_1	0.5647
p.S941F	TCGA-EE-A2GI	SKCM	TCGA	SPETPVPSP	DEG_COP1_1	0.1389
p.S941F	DO222595	MELA	ICGC	SPETPVPSP	DEG_COP1_1	0.1389
p.S941F	DO37410	SKCM	ICGC	SPETPVPSP	DEG_COP1_1	0.1389
p.P936S	TCGA-FR-A726	SKCM	TCGA	SPETPVPSP	DEG_COP1_1	0.2778
p.P936S	TCGA-W3-A824	SKCM	TCGA	SPETPVPSP	DEG_COP1_1	0.2778
p.P936S	DO48665	SKCM	ICGC	SPETPVPSP	DEG_COP1_1	0.2778
p.P936S	DO51271	SKCM	ICGC	SPETPVPSP	DEG_COP1_1	0.2778
p.P936S	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	SPETPVPSP	DEG_COP1_1	0.2778
p.P936S	ACH-001642	Lymphoma	CCLE	SPETPVPSP	DEG_COP1_1	0.2778
p.P936S	SCC-3	haematopoietic_and_lymphoid_tissue	COSMIC	SPETPVPSP	DEG_COP1_1	0.2778
p.P939L	TCGA-FW-A3R5	SKCM	TCGA	SPETPVPSP	DEG_COP1_1	0.1944
p.P939L	DO37406	SKCM	ICGC	SPETPVPSP	DEG_COP1_1	0.1944
p.S935F	TCGA-YD-A9TA	SKCM	TCGA	SPETPVPSP	DEG_COP1_1	0.3056
p.S935F	DO229453	SKCA	ICGC	SPETPVPSP	DEG_COP1_1	0.3056
p.S935F	DO219503	SKCM	ICGC	SPETPVPSP	DEG_COP1_1	0.3056
p.S933F	DO229456	SKCA	ICGC	SPETPVPSP	DEG_COP1_1	0.7982
p.D921G	SIDM00135	Breast Carcinoma	GDSC	SPETPVPSP	DEG_COP1_1	0.1944
p.D921G	ACH-000148	Breast Cancer	CCLE	SPETPVPSP	DEG_COP1_1	0.1944
p.D921G	Hs-578-T	breast	COSMIC	SPETPVPSP	DEG_COP1_1	0.1944
p.P934S	SIDM00003	Melanoma	GDSC	SPETPVPSP	DEG_COP1_1	0.6752
p.P934S	ACH-002159	Skin Cancer	CCLE	SPETPVPSP	DEG_COP1_1	0.6752
p.P934S	M14	skin	COSMIC	SPETPVPSP	DEG_COP1_1	0.6752
p.A916V	ACH-001853	Bile Duct Cancer	CCLE	SPETPVPSP	DEG_COP1_1	0.0556
p.T929N	ACH-002446	Gastric Cancer	CCLE	SPETPVPSP	DEG_COP1_1	0.7055

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SPETPVPSP

Degron related mutations and impact score

Drug responses associated with CLCN1 mutations

All proteins holding degron of SPETPVPSP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35523	Chloride channel protein 1	DEG_COP1_1	926:934	SPETPVPSP	COP1	0.9812	More...