DegronMD

Uniprot ID: P49418

Source protein: Amphiphysin

Source gene: AMPH

Class: DEG_SCF_FBW7_1

Location: 361:368

E3 ligase: FBXW7

DEGRON score: 0.9979

ASA_SCORE: 76.6375

COIL: 0.9404

CONS_SCORE: 0.2742

DSS_SCORE: 0.5406

HELIX: 0.02

FCONS_SCORE: 0.8679

RIG_SCORE: 0.6845

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S377F	TCGA-18-3409	LUSC	TCGA	PEVTPAGS	DEG_SCF_FBW7_1	0.0833
p.S377F	DO26444	LUSC	ICGC	PEVTPAGS	DEG_SCF_FBW7_1	0.0833
p.S377C	TCGA-22-4599	LUSC	TCGA	PEVTPAGS	DEG_SCF_FBW7_1	0.0833
p.S377C	DO26945	LUSC	ICGC	PEVTPAGS	DEG_SCF_FBW7_1	0.0833
p.S377C	ACH-001591	Lung Cancer	CCLE	PEVTPAGS	DEG_SCF_FBW7_1	0.0833
p.S377C	NCI-H1417	lung	COSMIC	PEVTPAGS	DEG_SCF_FBW7_1	0.0833
p.V363G	TCGA-77-8009	LUSC	TCGA	PEVTPAGS	DEG_SCF_FBW7_1	0.6421
p.V363G	DO27200	LUSC	ICGC	PEVTPAGS	DEG_SCF_FBW7_1	0.6421
p.D355Y	TCGA-77-8133	LUSC	TCGA	PEVTPAGS	DEG_SCF_FBW7_1	0.1667
p.D355Y	DO27039	LUSC	ICGC	PEVTPAGS	DEG_SCF_FBW7_1	0.1667
p.L354M	TCGA-A5-A2K5	UCEC	TCGA	PEVTPAGS	DEG_SCF_FBW7_1	0.1389
p.L354M	DO41379	UCEC	ICGC	PEVTPAGS	DEG_SCF_FBW7_1	0.1389
p.F359L	TCGA-AO-A03M	BRCA	TCGA	PEVTPAGS	DEG_SCF_FBW7_1	0.2778
p.F359L	DO2216	BRCA	ICGC	PEVTPAGS	DEG_SCF_FBW7_1	0.2778
p.F359L	DO221545	PACA	ICGC	PEVTPAGS	DEG_SCF_FBW7_1	0.2778
p.D357Y	TCGA-EE-A20C	SKCM	TCGA	PEVTPAGS	DEG_SCF_FBW7_1	0.2222
p.D357Y	DO47665	SKCM	ICGC	PEVTPAGS	DEG_SCF_FBW7_1	0.2222
p.P361L	TCGA-IB-7651	PAAD	TCGA	PEVTPAGS	DEG_SCF_FBW7_1	0.6471
p.P361L	DO46657	PAAD	ICGC	PEVTPAGS	DEG_SCF_FBW7_1	0.6471
p.H373Q	TCGA-UF-A71B	HNSC	TCGA	PEVTPAGS	DEG_SCF_FBW7_1	0.1944
p.H373Q	DO52107	HNSC	ICGC	PEVTPAGS	DEG_SCF_FBW7_1	0.1944
p.P365T	DO228976	LICA	ICGC	PEVTPAGS	DEG_SCF_FBW7_1	0.7031
p.P365T	SIDM00210	Ovarian Carcinoma	GDSC	PEVTPAGS	DEG_SCF_FBW7_1	0.7031
p.P365T	ACH-000657	Ovarian Cancer	CCLE	PEVTPAGS	DEG_SCF_FBW7_1	0.7031
p.P365T	A2780	ovary	COSMIC	PEVTPAGS	DEG_SCF_FBW7_1	0.7031
p.T364K	DO229028	LICA	ICGC	PEVTPAGS	DEG_SCF_FBW7_1	0.7306
p.D355N	DO220891	MELA	ICGC	PEVTPAGS	DEG_SCF_FBW7_1	0.1667
p.E362K	DO222420	MELA	ICGC	PEVTPAGS	DEG_SCF_FBW7_1	0.591
p.E362K	SIDM01442	Glioma	GDSC	PEVTPAGS	DEG_SCF_FBW7_1	0.591
p.E362K	ACH-000807	Brain Cancer	CCLE	PEVTPAGS	DEG_SCF_FBW7_1	0.591
p.P358S	DO222868	MELA	ICGC	PEVTPAGS	DEG_SCF_FBW7_1	0.25
p.M376I	SIDM00672	Hepatocellular Carcinoma	GDSC	PEVTPAGS	DEG_SCF_FBW7_1	0.1111
p.M376I	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PEVTPAGS	DEG_SCF_FBW7_1	0.1111
p.M376I	SIDM00969	Ovarian Carcinoma	GDSC	PEVTPAGS	DEG_SCF_FBW7_1	0.1111
p.M376I	SIDM00690	Head and Neck Carcinoma	GDSC	PEVTPAGS	DEG_SCF_FBW7_1	0.1111
p.M376I	SIDM00210	Ovarian Carcinoma	GDSC	PEVTPAGS	DEG_SCF_FBW7_1	0.1111
p.M376I	SIDM00928	Breast Carcinoma	GDSC	PEVTPAGS	DEG_SCF_FBW7_1	0.1111
p.M376I	SIDM01039	Other Solid Cancers	GDSC	PEVTPAGS	DEG_SCF_FBW7_1	0.1111
p.M376I	SIDM00879	Breast Carcinoma	GDSC	PEVTPAGS	DEG_SCF_FBW7_1	0.1111
p.M376I	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PEVTPAGS	DEG_SCF_FBW7_1	0.1111
p.M376I	SIDM00849	Kidney Carcinoma	GDSC	PEVTPAGS	DEG_SCF_FBW7_1	0.1111
p.M376I	SIDM01147	Gastric Carcinoma	GDSC	PEVTPAGS	DEG_SCF_FBW7_1	0.1111
p.M376I	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PEVTPAGS	DEG_SCF_FBW7_1	0.1111
p.M376I	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PEVTPAGS	DEG_SCF_FBW7_1	0.1111
p.M376I	SIDM01387	Small Cell Lung Carcinoma	GDSC	PEVTPAGS	DEG_SCF_FBW7_1	0.1111
p.P375A	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	PEVTPAGS	DEG_SCF_FBW7_1	0.1389
p.P375A	ACH-000757	Lung Cancer	CCLE	PEVTPAGS	DEG_SCF_FBW7_1	0.1389
p.P375A	A427	lung	COSMIC	PEVTPAGS	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PEVTPAGS

Degron related mutations and impact score

Drug responses associated with AMPH mutations

All proteins holding degron of PEVTPAGS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49418	Amphiphysin	DEG_SCF_FBW7_1	361:368	PEVTPAGS	FBXW7	0.9979	More...