DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PFSTPVRS
Uniprot ID:
Q13322
Source protein:
Growth factor receptor-bound protein 10
Source gene:
GRB10
Class:
DEG_SCF_FBW7_1
Location:
419:426
E3 ligase:
FBXW7
DEGRON score:
0.9858
ASA_SCORE:
67.6375
COIL:
0.7516
CONS_SCORE:
0.403
DSS_SCORE:
0.2798
HELIX:
0.0745
FCONS_SCORE:
0.8245
RIG_SCORE:
0.7379
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T422M
TCGA-28-5211
GBM
TCGA
PFSTPVRS
DEG_SCF_FBW7_1
0.8534
p.T422M
TCGA-D1-A160
UCEC
TCGA
PFSTPVRS
DEG_SCF_FBW7_1
0.8534
p.T422M
TCGA-D1-A17U
UCEC
TCGA
PFSTPVRS
DEG_SCF_FBW7_1
0.8534
p.S431C
TCGA-34-2605
LUSC
TCGA
PFSTPVRS
DEG_SCF_FBW7_1
0.6389
p.R425H
TCGA-AP-A1DV
UCEC
TCGA
PFSTPVRS
DEG_SCF_FBW7_1
0.7133
p.S421L
TCGA-DE-A0Y3
THCA
TCGA
PFSTPVRS
DEG_SCF_FBW7_1
0.7667
p.S421L
ACH-001513
Cervical Cancer
CCLE
PFSTPVRS
DEG_SCF_FBW7_1
0.7667
p.E429D
TCGA-EO-A3B0
UCEC
TCGA
PFSTPVRS
DEG_SCF_FBW7_1
0.25
p.I413V
DO9756
COAD
ICGC
PFSTPVRS
DEG_SCF_FBW7_1
0.1667
p.S426I
DO11411
GBM
ICGC
PFSTPVRS
DEG_SCF_FBW7_1
0.8453
p.S426I
DO229229
THCA
ICGC
PFSTPVRS
DEG_SCF_FBW7_1
0.8453
p.R410W
DO229063
LICA
ICGC
PFSTPVRS
DEG_SCF_FBW7_1
0.0833
p.G415C
DO26471
LUSC
ICGC
PFSTPVRS
DEG_SCF_FBW7_1
0.2222
p.G415C
DO41361
UCEC
ICGC
PFSTPVRS
DEG_SCF_FBW7_1
0.2222
p.PL419PF
DO222363
MELA
ICGC
PFSTPVRS
DEG_SCF_FBW7_1
0.7897
p.P422L
DO37782
SKCM
ICGC
PFSTPVRS
DEG_SCF_FBW7_1
0.7582
p.R431M
DO41488
UCEC
ICGC
PFSTPVRS
DEG_SCF_FBW7_1
0.6389
p.S418I
DO41361
UCEC
ICGC
PFSTPVRS
DEG_SCF_FBW7_1
0.75
p.E413A
SIDM01611
Endometrial Carcinoma
GDSC
PFSTPVRS
DEG_SCF_FBW7_1
0.1667
p.E429K
ACH-000383
Esophageal Cancer
CCLE
PFSTPVRS
DEG_SCF_FBW7_1
0.25
p.E429K
OE33
oesophagus
COSMIC
PFSTPVRS
DEG_SCF_FBW7_1
0.25
p.D436Y
ACH-002181
Ovarian Cancer
CCLE
PFSTPVRS
DEG_SCF_FBW7_1
0.0556
p.D436Y
OVCA420
ovary
COSMIC
PFSTPVRS
DEG_SCF_FBW7_1
0.0556
p.H430R
GR-ST
haematopoietic_and_lymphoid_tissue
COSMIC
PFSTPVRS
DEG_SCF_FBW7_1
0.2222
p.P419L
SK-MEL-24
skin
COSMIC
PFSTPVRS
DEG_SCF_FBW7_1
0.6471
p.E423K
OE33
oesophagus
COSMIC
PFSTPVRS
DEG_SCF_FBW7_1
0.7022
p.D430Y
OVCA420
ovary
COSMIC
PFSTPVRS
DEG_SCF_FBW7_1
0.2222
p.P431L
SK-MEL-24
skin
COSMIC
PFSTPVRS
DEG_SCF_FBW7_1
0.6389
Drug responses associated with GRB10 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PFSTPVRS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q13322
Growth factor receptor-bound protein 10
DEG_SCF_FBW7_1
419:426
PFSTPVRS
FBXW7
0.9858
More...