DegronMD - Q13322(GRB10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T422M	TCGA-28-5211	GBM	TCGA	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.8534
p.T422M	TCGA-D1-A160	UCEC	TCGA	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.8534
p.T422M	TCGA-D1-A17U	UCEC	TCGA	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.8534
p.S431C	TCGA-34-2605	LUSC	TCGA	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation blocking phosphorylation signal	0.6389
p.G177E	TCGA-44-7659	LUAD	TCGA	VKVFSE	LIG_APCC_ABBA_1	170:175	Mutation rewiring degron network	0.2778
p.R425H	TCGA-AP-A1DV	UCEC	TCGA	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.7133
p.S421L	TCGA-DE-A0Y3	THCA	TCGA	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.7667
p.S421L	ACH-001513	Cervical Cancer	CCLE	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.7667
p.E429D	TCGA-EO-A3B0	UCEC	TCGA	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.25
p.A165T	TCGA-G4-6303	COAD	TCGA	VKVFSE	LIG_APCC_ABBA_1	170:175	Mutation rewiring degron network	0.1944
p.P161A	TCGA-GV-A3JZ	BLCA	TCGA	VKVFSE	LIG_APCC_ABBA_1	170:175	Mutation rewiring degron network	0.0833
p.V170G	TCGA-IB-7651	PAAD	TCGA	VKVFSE	LIG_APCC_ABBA_1	170:175	Mutation altering degron motif	0.7532
p.A166T	TCGA-L5-A43J	ESCA	TCGA	VKVFSE	LIG_APCC_ABBA_1	170:175	Mutation rewiring degron network	0.2222
p.A166T	ACH-000874	Leukemia	CCLE	VKVFSE	LIG_APCC_ABBA_1	170:175	Mutation rewiring degron network	0.2222
p.A166T	ACH-000989	Colon/Colorectal Cancer	CCLE	VKVFSE	LIG_APCC_ABBA_1	170:175	Mutation rewiring degron network	0.2222
p.A166T	SNU-175	large intestine	COSMIC	VKVFSE	LIG_APCC_ABBA_1	170:175	Mutation rewiring degron network	0.2222
p.A166T	RS4-11	haematopoietic and lymphoid tissue	COSMIC	VKVFSE	LIG_APCC_ABBA_1	170:175	Mutation rewiring degron network	0.2222
p.I413V	DO9756	COAD	ICGC	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.1667
p.S426I	DO11411	GBM	ICGC	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.8453
p.S426I	DO229229	THCA	ICGC	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.8453
p.R410W	DO229063	LICA	ICGC	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.0833
p.G415C	DO26471	LUSC	ICGC	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.2222
p.G415C	DO41361	UCEC	ICGC	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.2222
p.PL419PF	DO222363	MELA	ICGC	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.7897
p.P422L	DO37782	SKCM	ICGC	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.7582
p.T178I	DO43891	UCEC	ICGC	VKVFSE	LIG_APCC_ABBA_1	170:175	Mutation rewiring degron network	0.25
p.R431M	DO41488	UCEC	ICGC	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation blocking phosphorylation signal	0.6389
p.S418I	DO41361	UCEC	ICGC	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation blocking phosphorylation signal	0.75
p.E413A	SIDM01611	Endometrial Carcinoma	GDSC	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.1667
p.E429K	ACH-000383	Esophageal Cancer	CCLE	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.25
p.E429K	OE33	oesophagus	COSMIC	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.25
p.P160T	ACH-000475	Liver Cancer	CCLE	VKVFSE	LIG_APCC_ABBA_1	170:175	Mutation rewiring degron network	0.0556
p.P160T	huH-1	liver	COSMIC	VKVFSE	LIG_APCC_ABBA_1	170:175	Mutation rewiring degron network	0.0556
p.D436Y	ACH-002181	Ovarian Cancer	CCLE	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.0556
p.D436Y	OVCA420	ovary	COSMIC	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.0556
p.H430R	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.2222
p.P419L	SK-MEL-24	skin	COSMIC	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.6471
p.E423K	OE33	oesophagus	COSMIC	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation altering degron motif	0.7022
p.D430Y	OVCA420	ovary	COSMIC	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation rewiring degron network	0.2222
p.A160T	RS4-11	haematopoietic and lymphoid tissue	COSMIC	VKVFSE	LIG_APCC_ABBA_1	170:175	Mutation rewiring degron network	0.0556
p.A160T	SNU-175	large intestine	COSMIC	VKVFSE	LIG_APCC_ABBA_1	170:175	Mutation rewiring degron network	0.0556
p.P431L	SK-MEL-24	skin	COSMIC	PFSTPVRS	DEG_SCF_FBW7_1	419:426	Mutation blocking phosphorylation signal	0.6389

Kaplan plot for GRB10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GRB10

UniProt ID: Q13322

Entrez ID: 2887

Protein name: Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GRB10 in