DegronMD

Uniprot ID: Q13322

Source protein: Growth factor receptor-bound protein 10

Source gene: GRB10

Class: LIG_APCC_ABBA_1

Location: 170:175

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.934

ASA_SCORE: 61.3333

COIL: 0.3495

CONS_SCORE: 0.5789

DSS_SCORE: 0.3851

HELIX: 0.0042

FCONS_SCORE: 1.3851

RIG_SCORE: 0.7709

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G177E	TCGA-44-7659	LUAD	TCGA	VKVFSE	LIG_APCC_ABBA_1	0.2778
p.A165T	TCGA-G4-6303	COAD	TCGA	VKVFSE	LIG_APCC_ABBA_1	0.1944
p.P161A	TCGA-GV-A3JZ	BLCA	TCGA	VKVFSE	LIG_APCC_ABBA_1	0.0833
p.V170G	TCGA-IB-7651	PAAD	TCGA	VKVFSE	LIG_APCC_ABBA_1	0.7532
p.A166T	TCGA-L5-A43J	ESCA	TCGA	VKVFSE	LIG_APCC_ABBA_1	0.2222
p.A166T	ACH-000874	Leukemia	CCLE	VKVFSE	LIG_APCC_ABBA_1	0.2222
p.A166T	ACH-000989	Colon/Colorectal Cancer	CCLE	VKVFSE	LIG_APCC_ABBA_1	0.2222
p.A166T	SNU-175	large_intestine	COSMIC	VKVFSE	LIG_APCC_ABBA_1	0.2222
p.A166T	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	VKVFSE	LIG_APCC_ABBA_1	0.2222
p.T178I	DO43891	UCEC	ICGC	VKVFSE	LIG_APCC_ABBA_1	0.25
p.P160T	ACH-000475	Liver Cancer	CCLE	VKVFSE	LIG_APCC_ABBA_1	0.0556
p.P160T	huH-1	liver	COSMIC	VKVFSE	LIG_APCC_ABBA_1	0.0556
p.A160T	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	VKVFSE	LIG_APCC_ABBA_1	0.0556
p.A160T	SNU-175	large_intestine	COSMIC	VKVFSE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13322	Growth factor receptor-bound protein 10	LIG_APCC_ABBA_1	170:175	VKVFSE	APC,CDC20,FZR1	0.934	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons